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Source: Am J Physiol Cell Ph...
Condition: Interstitial Lung Disease
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Total 5 results found since Jan 2013.
MARCH8 downregulation modulates profibrotic responses including myofibroblast differentiation
In this study, we demonstrated decreased MARCH8 expression in IPF patients compared to non-PF controls and in bleomycin induced PF. TGF-β dose and time dependently decreased MARCH8 expression in normal and IPF human lung fibroblast (HLFs), along with induction of FMT markers α-SMA, collagen type I (Col-1), and fibronectin (FN). Interestingly, overexpression of MARCH8 significantly suppressed TGF-β-induced expression of α-SMA, Col-1, and FN. By contrast, knockdown of MARCH8 using siRNA upregulated basal expression of α-SMA/Col-1/FN. Moreover, MARCH8 knockdown enhanced TGF-β-induced FMT marker expression. These data cl...
Source: Am J Physiol Cell Ph... - September 4, 2023 Category: Cytology Authors: Xia Guo Oluwaseun Adeyanju Ayobami Matthew Olajuyin Venkatakirankumar Mandlem Christudas Sunil Joy Adewumi Steven Huang Torry A Tucker Steven Idell Guoqing Qian Source Type: research
