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Down-regulation of ATAD2 restrains cancer stem cell properties in esophageal squamous cell carcinoma via blockade of the Hedgehog signaling pathway.
Abstract Esophageal squamous cell carcinoma (ESCC) ranks among the five most common cancers in China, and has a five-year survival rate of less than 15%. The transcription factor ATAD2 has potential as a therapeutic target in various tumors, and microarray-based gene expression profiling reveals dysregulation of ATAD2 specifically in ESCC. Here we investigated whether ATAD2 could mediate a regulation of cancer stem cell (CSC) biological functions in ESCC. Immunohistochemical staining, reverse transcription quantitative polymerase chain reaction, and Western blot assays all revealed up-regulation of ATAD2 in ESCC t...
Source: Am J Physiol Cell Ph... - November 19, 2019 Category: Cytology Authors: Li N, Yu Y, Wang B Tags: Am J Physiol Cell Physiol Source Type: research

Specific knockdown of HOXB7 inhibits cutaneous squamous cell carcinoma cell migration and invasion while inducing apoptosis via the Wnt/ β-catenin signaling pathway.
Specific knockdown of HOXB7 inhibits cutaneous squamous cell carcinoma cell migration and invasion while inducing apoptosis via the Wnt/β-catenin signaling pathway. Am J Physiol Cell Physiol. 2018 Nov 01;315(5):C675-C686 Authors: Gao D, Chen HQ Abstract Metastatic cutaneous squamous cell carcinoma (CSCC) is a major cause of death associated with nonmelanoma skin cancer. The involvement of homeobox B7 ( HOXB7) in cancers has been reported. Thus, the current study intends to explore the effect of HOXB7 on CSCC and its relationship with the Wnt/β-catenin signaling pathway. Initially, microarray-based g...
Source: Am J Physiol Cell Ph... - November 1, 2018 Category: Cytology Authors: Gao D, Chen HQ Tags: Am J Physiol Cell Physiol Source Type: research

Specific knockdown of HOXB7 inhibits cutaneous squamous cell carcinoma cell migration and invasion while inducing apoptosis via Wnt/ β-catenin signaling pathway.
Specific knockdown of HOXB7 inhibits cutaneous squamous cell carcinoma cell migration and invasion while inducing apoptosis via Wnt/β-catenin signaling pathway. Am J Physiol Cell Physiol. 2018 Aug 01;: Authors: Gao D, Chen HQ, Yang YM Abstract Metastatic cutaneous squamous cell carcinoma (CSCC) is a major cause of death associated with non-melanoma skin cancer. The involvement of homeobox B7 (HOXB7) in cancers has been reported. Thus, the current study intends to explore the effect of HOXB7 on CSCC and its relationship with the Wnt/β-catenin signaling pathway. Initially, microarray-based gene expres...
Source: Am J Physiol Cell Ph... - August 1, 2018 Category: Cytology Authors: Gao D, Chen HQ, Yang YM Tags: Am J Physiol Cell Physiol Source Type: research