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Impact of the histone deacetylase inhibitor Trichostatin A on active uptake, volume-sensitive release of taurine and cell fate in human ovarian cancer cells.
Abstract The HDAC inhibitor trichostatine A (TSA) reduces cell viability in cisplatin-sensitive (A2780WT) and cisplatin-resistant (A2780RES) human ovarian cancer cells due to progression of apoptosis (increased caspase 9 activity), autophagy (increased LC3II expression) and cell cycle arrest (increased p21 expression). The TSA-mediated effect on p21 and caspase 9 is mainly p53-independent. Cisplatin increases DNA-damage (histone H2AX phosphorylation) in A2780WT cells, whereas cisplatin, due to reduced uptake (inductively-coupled-plasma-mass-spectrometry Pt-analysis), has no DNA damaging effect in A2780RES cells. T...
Source: Am J Physiol Cell Ph... - January 7, 2020 Category: Cytology Authors: Lambert IH, Nielsen D, Stürup S Tags: Am J Physiol Cell Physiol Source Type: research

Down-regulation of ATAD2 restrains cancer stem cell properties in esophageal squamous cell carcinoma via blockade of the Hedgehog signaling pathway.
Abstract Esophageal squamous cell carcinoma (ESCC) ranks among the five most common cancers in China, and has a five-year survival rate of less than 15%. The transcription factor ATAD2 has potential as a therapeutic target in various tumors, and microarray-based gene expression profiling reveals dysregulation of ATAD2 specifically in ESCC. Here we investigated whether ATAD2 could mediate a regulation of cancer stem cell (CSC) biological functions in ESCC. Immunohistochemical staining, reverse transcription quantitative polymerase chain reaction, and Western blot assays all revealed up-regulation of ATAD2 in ESCC t...
Source: Am J Physiol Cell Ph... - November 19, 2019 Category: Cytology Authors: Li N, Yu Y, Wang B Tags: Am J Physiol Cell Physiol Source Type: research

Upregulated MicroRNA-141 Suppresses Epithelial-Mesenchymal Transition and Lymph Node Metastasis via HOXC6-Dependent TGF- β Signaling Pathway in Laryngeal Cancer.
This study investigated the roles of microRNA-141 (miR-141), Homeobox C6 (HOXC6), and the transforming growth factor-β (TGF-β) signaling pathway in epithelial-mesenchymal transition (EMT) and lymph node metastasis in laryngeal cancer. Initially, differentially expressed genes related to laryngeal cancer were retrieved, from which HOXC6 was identified. Next, HOXC6 was determined to be a target gene of miR-141. The regulatory relationship of miR-141, HOXC6 and the TGF-β signaling pathway were then explored accordingly. To further investigate the associated underlying mechanism, Hep-2 cells were transfected with miR-141 mi...
Source: Am J Physiol Cell Ph... - April 23, 2019 Category: Cytology Authors: Sun DZ, Wang XH, Fu YG, Yang PZ, Lv HQ, Yin YW, Zhang XY Tags: Am J Physiol Cell Physiol Source Type: research

Specific knockdown of HOXB7 inhibits cutaneous squamous cell carcinoma cell migration and invasion while inducing apoptosis via the Wnt/ β-catenin signaling pathway.
Specific knockdown of HOXB7 inhibits cutaneous squamous cell carcinoma cell migration and invasion while inducing apoptosis via the Wnt/β-catenin signaling pathway. Am J Physiol Cell Physiol. 2018 Nov 01;315(5):C675-C686 Authors: Gao D, Chen HQ Abstract Metastatic cutaneous squamous cell carcinoma (CSCC) is a major cause of death associated with nonmelanoma skin cancer. The involvement of homeobox B7 ( HOXB7) in cancers has been reported. Thus, the current study intends to explore the effect of HOXB7 on CSCC and its relationship with the Wnt/β-catenin signaling pathway. Initially, microarray-based g...
Source: Am J Physiol Cell Ph... - November 1, 2018 Category: Cytology Authors: Gao D, Chen HQ Tags: Am J Physiol Cell Physiol Source Type: research

Specific knockdown of HOXB7 inhibits cutaneous squamous cell carcinoma cell migration and invasion while inducing apoptosis via Wnt/ β-catenin signaling pathway.
Specific knockdown of HOXB7 inhibits cutaneous squamous cell carcinoma cell migration and invasion while inducing apoptosis via Wnt/β-catenin signaling pathway. Am J Physiol Cell Physiol. 2018 Aug 01;: Authors: Gao D, Chen HQ, Yang YM Abstract Metastatic cutaneous squamous cell carcinoma (CSCC) is a major cause of death associated with non-melanoma skin cancer. The involvement of homeobox B7 (HOXB7) in cancers has been reported. Thus, the current study intends to explore the effect of HOXB7 on CSCC and its relationship with the Wnt/β-catenin signaling pathway. Initially, microarray-based gene expres...
Source: Am J Physiol Cell Ph... - August 1, 2018 Category: Cytology Authors: Gao D, Chen HQ, Yang YM Tags: Am J Physiol Cell Physiol Source Type: research

PPARα inhibition modulates multiple reprogrammed metabolic pathways in kidney cancer and attenuates tumor growth.
Abstract Kidney cancer (RCC) is the 6(th) most common cancer in the US and its incidence is increasing. The current progression-free survival for patients with advanced RCC rarely extends beyond 1-2 years due to the development of therapeutic resistance. We previously identified PPARα as a potential therapeutic target for this disease and showed that a specific PPARα antagonist, GW6471, induced both apoptosis and cell cycle arrest at G0/G1 in RCC cell lines associated with attenuation of cell cycle regulatory proteins. We now extend that work and show that PPARα inhibition attenuates components of RCC metabolic...
Source: Am J Physiol Cell Ph... - March 25, 2015 Category: Cytology Authors: Abu Aboud O, Donohoe D, Bultman S, Fitch M, Riiff T, Hellerstein M, Weiss RH Tags: Am J Physiol Cell Physiol Source Type: research

PKCδ/Midkine Pathway Drives Hypoxia-induced Proliferation and Differentiation of Human Lung Epithelial Cells.
Abstract Epithelial cells are key players in the pathobiology of numerous hypoxia-induced lung diseases. The mechanisms mediating such hypoxic responses of epithelial cells are not well characterized. Earlier studies reported that hypoxia stimulates protein kinase C (PKC) δ activation in renal cancer cells and an increase in expression of a heparin-binding growth factor, midkine (MK) in lung alveolar epithelial cells. We reasoned that hypoxia might regulate MK levels via PKCδ-dependent pathway and hypothesized that PKCδ-driven MK expression is required for hypoxia-induced lung epithelial cell proliferation and ...
Source: Am J Physiol Cell Ph... - February 5, 2014 Category: Cytology Authors: Zhang H, Okamoto M, Panzhinskiy E, Zawada WM, Das M Tags: Am J Physiol Cell Physiol Source Type: research