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Lessons from SARS and MERS remind us of the possible therapeutic effects of implementing a siRNA strategy to target COVID-19: Shoot the messenger!
PMID: 32677763 [PubMed - as supplied by publisher]
Source: J Cell Mol Med - July 16, 2020 Category: Molecular Biology Authors: Habtemariam S, Berindan-Neagoe I, Cismaru CA, Schaafsma D, Nabavi SF, Ghavami S, Banach M, Nabavi SM Tags: J Cell Mol Med Source Type: research

Lymphoblastoid Cell Lines Models of Drug Response: Successes and Lessons from This Pharmacogenomic Model.
Abstract A new standard for medicine is emerging that aims to improve individual drug responses through studying associations with genetic variations. This field, pharmacogenomics, is undergoing a rapid expansion due to a variety of technological advancements that are enabling higher throughput with reductions in cost. Here we review the advantages, limitations, and opportunities for using lymphoblastoid cell lines (LCL) as a model system for human pharmacogenomic studies. There are a wide range of publicly available resources with genome-wide data available for LCLs from both related and unrelated populations, re...
Source: Current Molecular Medicine - August 11, 2014 Category: Molecular Biology Authors: Jack J, Rotroff D, Motsinger-Reif AA Tags: Curr Mol Med Source Type: research