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α5-nAChR modulates nicotine-induced cell migration and invasion in A549 lung cancer cells.
Abstract Cigarette smoking is the most important risk factor in the development of human lung cancer. Nicotine, the major component in tobacco, not only contributes to carcinogenesis but also promotes tumor metastasis. By binding to nicotinic acetylcholine receptors (nAChRs), nicotine induces the proliferation and migration of non-small cell lung cancer. Recently studies have indicated that α5-nAChR is highly associated with lung cancer risk and nicotine dependence. Nevertheless, it is unclear whether nicotine promotes the migration and invasion through activation of α5-nAChR in lung cancer. In the present study...
Source: Experimental and Toxicologic Pathology - July 20, 2015 Category: Pathology Authors: Sun H, Ma X Tags: Exp Toxicol Pathol Source Type: research