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Specialty: Endocrinology
Drug: Nicotine
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nAChR signaling regulates IRE1 α activation to protect β cells against terminal unfolded protein response under irremediable ER stress
ConclusionsOur findings suggest that nAChR signaling regulates IRE1 α activation to protect β cells from the T‐UPR and apoptosis under ER stress partly through α7 nAChR. Targeting nAChR signaling to inhibit the T‐UPR cascade may therefore hold therapeutic promise by thwarting β cell death in diabetes.
Source: Journal of Diabetes Investigation - January 9, 2020 Category: Endocrinology Authors: Tatsuya Ishibashi,
Shuhei Morita,
Shohei Kishimoto,
Shinsuke Uraki,
Ken Takeshima,
Yasushi Furukawa,
Hidefumi Inaba,
Hiroyuki Ariyasu,
Hiroshi Iwakura,
Hiroto Furuta,
Masahiro Nishi,
Feroz R. Papa,
Takashi Akamizu Tags: ORIGINAL ARTICLE Source Type: research
