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Nicotinic acid suppresses sebaceous lipogenesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA2 ).
Abstract Nicotinic acid (NA) activates hydroxycarboxylic acid receptor 2 (HCA2 ), and it is widely used in treating dyslipidaemias. Since its side effects include skin dryness, whereas its deficiency can be accompanied by dyssebacia, characterized by sebaceous gland enlargement, we asked if HCA2 is expressed on human sebocytes, and if NA influences sebocyte functions. By using human immortalized SZ95 sebocytes, we found that non-cytotoxic (≤100 μmol/L; MTT-assay) concentrations of NA had no effect on the homeostatic sebaceous lipogenesis (SLG; Nile Red), but normalized excessive, acne-mimicking SLG induced by ...
Source: J Cell Mol Med - July 4, 2019 Category: Molecular Biology Authors: Markovics A, Tóth KF, Sós KE, Magi J, Gyöngyösi A, Benyó Z, Zouboulis CC, Bíró T, Oláh A Tags: J Cell Mol Med Source Type: research

CD38 Mediates Angiotensin II-induced Intracellular Ca(2+) Release in Rat Pulmonary Arterial Smooth Muscle Cells.
This study sought to characterize its roles in angiotension II (Ang II)-induced Ca2+ release (AICR) in PASMCs. Examination of CD38 expression in various rat arteries found high levels of CD38 mRNA and protein in pulmonary arteries. Ang II elicited Ca2+ response consisted of extracellular Ca2+ influx and intracellular Ca2+ release in PASMCs. AICR activated in the absence of extracellular Ca2+ was reduced by pharmacological or siRNA inhibition of CD38. It was also reduced by the cADPR-antagonist 8-bromo-cADPR or ryanodine; and by the NAADP-antagonist Ned-19 or disruption of endolysosomal Ca2+ stores with the vacuolar H+-ATPa...
Source: American Journal of Respiratory Cell and Molecular Biology - July 31, 2014 Category: Molecular Biology Authors: Lee S, Paudel O, Jiang Y, Yang XR, Sham JS Tags: Am J Respir Cell Mol Biol Source Type: research