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Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway
Aging (Albany NY). 2021 Jun 11;13. doi: 10.18632/aging.203137. Online ahead of print.ABSTRACTDiabetic patients are more vulnerable to cerebral ischemia-reperfusion (CIR) injury and have a worse prognosis and higher mortality after ischemic stroke than non-diabetic counterparts. Melatonin can exert neuroprotective effects against CIR injury in nondiabetic animal models. However, its effects on diabetic CIR injury and the underlying mechanisms remain unclarified. Herein, we found that melatonin administration improved neurological deficit, cerebral infarct volume, brain edema, and cell viability, reduced mitochondrial swelli...
Source: Aging - June 12, 2021 Category: Biomedical Science Authors: Lian Liu Quan Cao Wenwei Gao Bingyu Li Zhongyuan Xia Bo Zhao Source Type: research

Melatonin attenuates smoking-induced atherosclerosis by activating the Nrf2 pathway via NLRP3 inflammasomes in endothelial cells
Aging (Albany NY). 2021 Apr 4;13. doi: 10.18632/aging.202829. Online ahead of print.ABSTRACTSubstantial evidence suggests that the effects of smoking in atherosclerosis are associated with inflammation mediated by endothelial cells. However, the mechanisms and potential drug therapies for smoking-induced atherosclerosis remain to be clarified. Considering that melatonin exerts beneficial effects in cardiovascular diseases, we examined its effects on cigarette smoke-induced vascular injury. We found that cigarette smoke extract (CSE) treatment induced NLRP3-related pyroptosis in human aortic endothelial cells (HAECs). CSE a...
Source: Aging - April 11, 2021 Category: Biomedical Science Authors: Zhewei Zhao Xuebin Wang Rui Zhang Baitao Ma Shuai Niu Xiao Di Leng Ni Changwei Liu Source Type: research

Melatonin induces progesterone production in human granulosa-lutein cells through upregulation of StAR expression.
Abstract Steroidogenic acute regulatory protein (StAR) mediates the rate-limiting step in ovarian steroidogenesis and progesterone (P4) synthesis. Melatonin and its receptors are expressed in human granulosa cells, and have been shown to influence basal P4 production. However, previous studies addressing the regulation of StAR expression by melatonin and its impact on P4 secretion yielded contradictory results. Here, we demonstrate that melatonin upregulates StAR expression in primary cultures of human granulosa-lutein (hGL) cells obtained from women undergoing in vitro fertilization (IVF). Using pharmacological i...
Source: Aging - October 15, 2019 Category: Biomedical Science Authors: Fang L, Li Y, Wang S, Yu Y, Li Y, Guo Y, Yan Y, Sun YP Tags: Aging (Albany NY) Source Type: research