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Melatonin attenuates MPP < sup > + < /sup > -induced apoptosis via heat shock protein in a Parkinson's disease model
Biochem Biophys Res Commun. 2022 Jul 1;621:59-66. doi: 10.1016/j.bbrc.2022.06.099. Online ahead of print.ABSTRACTHeat shock proteins (HSPs) play an essential role as molecular chaperones to prevent abnormal protein aggregation and misfolding. Moreover, they protect dopamine neurons from oxidative stress, inflammation, and apoptosis, all well-known pathomechanisms of Parkinson's disease (PD). Melatonin is a potent antioxidant that has the beneficial ability to prevent neurodegenerative diseases like PD. We aimed to explore the protective properties of melatonin in an in vitro PD model, focusing on its underlying mechanism u...
Source: Biochemical and Biophysical Research communications - July 10, 2022 Category: Biochemistry Authors: Yu Jin Jung Hyunsu Choi Eungseok Oh Source Type: research

Melatonin receptor depletion suppressed hCG-induced testosterone expression in mouse Leydig cells.
In this study, immunolocalization assay showed that MT1 and MT2 are highly expressed in Leydig cell membrane. To understand the biological function of melatonin receptors in hCG-induced testosterone synthesis, we generated melatonin receptor knockdown cells using specific siRNA and performed testosterone detection after hCG treatment. We found that knockdown of melatonin receptors, especially MTNR1A, led to an obvious decrease (> 60%) of testosterone level. Our further study revealed that knockdown of melatonin receptors repressed expression, at both the mRNA level and the protein level, of key steroidogenic genes, su...
Source: Cellular and Molecular Biology Letters - March 28, 2019 Category: Biochemistry Authors: Gao Y, Wu X, Zhao S, Zhang Y, Ma H, Yang Z, Yang W, Zhao C, Wang L, Zhang Q Tags: Cell Mol Biol Lett Source Type: research

Trek2a regulates gnrh3 expression under control of melatonin receptor Mt1 and α2-adrenoceptor.
Abstract Gonadotrophin-releasing hormone (GnRH) expression is associated with the two-pore domain potassium ion (K+) channel-related K+ (TREK) channel trek2a expression and melatonin levels. We aimed to investigate correlation of trek2a expression with gnrh3 expression, and regulatory mechanisms of trek2a expression by the melatonin receptor Mt1 and α2-adrenoceptor which are regulated by melatonin. trek2a specific siRNA, Mt1 antagonist luzindole and α2-adrenoceptor antagonist prazosin were administered into the adult zebrafish brain and gene expressions were examined by real-time PCR. trek2a specific siRNA admin...
Source: Biochemical and Biophysical Research communications - February 7, 2018 Category: Biochemistry Authors: Loganathan K, Moriya S, Parhar IS Tags: Biochem Biophys Res Commun Source Type: research