Filtered By:
Drug: Magnesium

This page shows you your search results in order of date. This is page number 6.

Order by Relevance | Date

Total 77 results found since Jan 2013.

CCN1/Cyr61-PI3K/AKT signaling promotes retinal neovascularization in oxygen-induced retinopathy.
Abstract Retinal neovascularization (RNV) is a characteristic pathological finding of retinopathy of prematurity (ROP). Cysteine-rich 61 [Cyr61, also known as CCN family member 1 (CCN1)] has been reported to mediate angiogenesis. The aim of the present study was to investigate the mechanisms of CCN1/Cyr61-phosphoinositide 3-kinase (PI3K)/AKT signaling in ROP. The contribution of CCN1 to human umbilical vein endothelial cell (HUVEC) proliferation and apoptosis under hypoxic conditions was determined using a cell counting kit‑8 (CCK-8) and Annexin V/propidium iodide (PI) staining, respectively, as well as...
Source: International Journal of Molecular Medicine - October 12, 2015 Category: Molecular Biology Authors: Di Y, Zhang Y, Nie Q, Chen X Tags: Int J Mol Med Source Type: research

DNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase
The triazine derivative 12459 is a potent G-quadruplex ligand that triggers apoptosis or delayed growth arrest, telomere shortening and G-overhang degradation, as a function of its concentration and time exposure to the cells. We have investigated here the DNA damage response induced by 12459 in A549 cells. Submicromolar concentrations of 12459 triggers a delayed Chk1-ATR–mediated DNA damage response associated with a telomeric dysfunction and a G2/M arrest. Surprisingly, increasing concentrations of 12459 leading to cell apoptosis induced a mechanism that bypasses the DNA damage signaling and leads to the dephosphor...
Source: Nucleic Acids Research - March 31, 2013 Category: Research Authors: Douarre, C., Mergui, X., Sidibe, A., Gomez, D., Alberti, P., Mailliet, P., Trentesaux, C., Riou, J.-F. Tags: Genome Integrity, Repair and Replication Source Type: research