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Fibroblast growth factor 2 mRNA expression evoked by amitriptyline involves extracellular signal‐regulated kinase‐dependent early growth response 1 production in rat primary cultured astrocytes
This study defined the signaling cascade that mediates amitriptyline‐induced FGF2 production in rat primary cultured astrocytes. Amitriptyline treatment significantly increased early growth response 1 (EGR1), a transcription factor known to regulate FGF2 expression. Knockdown of EGR1 using siRNA blocked amitriptyline‐evoked FGF2 mRNA expression. Treatment with several different classes of antidepressants leads to expression of EGR1 mRNA as well as FGF2 mRNA. These results confirm that EGR1 production is likely to be indispensable for the amitriptyline‐evoked FGF2 mRNA expression. Signal transduction inhibitors were u...
Source: Journal of Neurochemistry - August 6, 2015 Category: Neurology Authors: Naoto Kajitani, Kazue Hisaoka‐Nakashima, Mami Okada‐Tsuchioka, Mayu Hosoi, Toshiki Yokoe, Norimitsu Morioka, Yoshihiro Nakata, Minoru Takebayashi Tags: Original Article Source Type: research

Fibroblast growth factor 2 mRNA expression evoked by amitriptyline involves ERK‐dependent EGR1 production in rat primary cultured astrocytes
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - July 16, 2015 Category: Neurology Authors: Naoto Kajitani, Kazue Hisaoka‐Nakashima, Mami Okada‐Tsuchioka, Mayu Hosoi, Toshiki Yokoe, Norimitsu Morioka, Yoshihiro Nakata, Minoru Takebayashi Tags: Original Article Source Type: research