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Calpain-2 plays a pivotal role in the inhibitory effects of propofol against TNF- α-induced autophagy in mouse hippocampal neurons.
Calpain-2 plays a pivotal role in the inhibitory effects of propofol against TNF-α-induced autophagy in mouse hippocampal neurons. J Cell Mol Med. 2020 Jul 06;: Authors: Li Y, He Z, Lv H, Chen W, Chen J Abstract Calpains are calcium-dependent proteases and play critical roles in neuronal autophagy induced by inflammation. Propofol has been reported to exert anti-inflammatory effects in neurons. We aimed to identify whether and how propofol-modulated calpain activity and neuron autophagy in response to tumour necrosis factor-α (TNF-α). Mouse hippocampal neurons were pre-treated with propofol and exp...
Source: J Cell Mol Med - July 5, 2020 Category: Molecular Biology Authors: Li Y, He Z, Lv H, Chen W, Chen J Tags: J Cell Mol Med Source Type: research