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Total 35 results found since Jan 2013.
γ-Aminobutyric Acid-Ergic Development Contributes to the Enhancement of Electroencephalogram Slow-Delta Oscillations Under Volatile Anesthesia in Neonatal Rats
CONCLUSIONS: Enhancement of cortical EEG slow-delta oscillations by volatile anesthetics may require mature GABAergic inhibitory transmission during neonatal development.PMID:36753442 | DOI:10.1213/ANE.0000000000006396
Source: Anesthesia and Analgesia - February 8, 2023 Category: Anesthesiology Authors: Mingyue Zhang Yali Chen Ting Xu Jingyao Jiang Donghang Zhang Han Huang Charles D Kurth Ian Yuan Rurong Wang Jin Liu Tao Zhu Cheng Zhou Source Type: research
Function of connexin 43 and RhoA/LIMK2/Cofilin signaling pathway in transient changes of contraction and dilation of human umbilical arterial smooth muscle cells
CONCLUSION: The function of Cx43-GJs lies in the center of Ang Ⅱ-induced contraction of HUASMCs, which potentially regulates intracellular Ca2+ mobility as well as RhoA/LIMK2/Cofilin signaling pathway activity. Propofol can reverse this effect induced by Ang Ⅱ through suppressing the function of Cx43-GJs.PMID:36330887 | DOI:10.1016/j.biocel.2022.106326
Source: The International Journal of Biochemistry and Cell Biology - November 4, 2022 Category: Biochemistry Authors: Zhizhao Deng Yanling Zhang Qian Zhang Xianlong Li Weiqi Zeng Cai Jun Dongdong Yuan Source Type: research
Protection of propofol on liver ischemia reperfusion injury by regulating Cyp2b10/ Cyp3a25 pathway
Tissue Cell. 2022 Aug 6;78:101891. doi: 10.1016/j.tice.2022.101891. Online ahead of print.ABSTRACTTo verify whether propofol alleviates liver ischemia-reperfusion injury (IRI) in mice by regulating Cyp2b10/ Cyp3a25 pathway. The liver I/R injury in vivo and in vitro model was constructed. The serum level of AST, ALT, ALP and ALB was detected using ELISA. The mRNA and protein expression of Cyp2b10 and Cyp3a25 were determined by qRT-PCR and western blot, respectively. The liver cell activity was assessed by MTT assay. The binding between Cyp2b10 and Cyp3a25 was evaluated by online website prediction, CoIP, and cell transfecti...
Source: Tissue and Cell - August 19, 2022 Category: Cytology Authors: Jinli Wu Chao Yu Xianggang Zeng Yini Xu Chengyi Sun Source Type: research
lncRNA BDNF-AS Attenuates Propofol-Induced Apoptosis in HT22 Cells by Modulating the BDNF/TrkB Pathway
This study aimed to investigate the involvement of BDNF-AS in propofol-induced apoptosis in HT22 cells. HT22 cells were treated with various concentrations of propofol at different time points. BDNF-AS was silenced using BDNF-AS-targeting siRNA. TrkB was antagonized by the TrkB inhibitor, ANA-12. Flow cytometry, quantitative reverse-transcription PCR, and western blotting were performed to analyze apoptosis and the expression of genes and proteins, respectively. In propofol-treated HT22 cells, BDNF-AS was upregulated, and BDNF was downregulated in a time- and dose-dependent manner. BDNF-AS downregulation mediated by siRNA ...
Source: Molecular Neurobiology - March 26, 2022 Category: Neurology Source Type: research
Propofol Protects Myocardium From Ischemia/Reperfusion Injury by Inhibiting Ferroptosis Through the AKT/p53 Signaling Pathway
The molecular mechanism underlying the protective role of propofol against myocardial ischemia/reperfusion (I/R) injury remains poorly understood. Previous studies have shown that ferroptosis is an imperative pathological process in myocardial I/R injury. We hypothesized that propofol prevents myocardial I/R injury by inhibiting ferroptosis via the AKT/p53 signaling pathway. The ferroptosis-inducing agent erastin (E) and AKT inhibitor MK2206 (MK) were used to investigate the role of propofol in myocardial I/R injury. H9C2 cells treated without any reagents, erastin for 24 h, propofol for 1 h before adding erastin were as...
Source: Frontiers in Pharmacology - March 16, 2022 Category: Drugs & Pharmacology Source Type: research
Propofol inhibits proliferation and migration of glioma cells by up-regulating lncRNA GAS5
Toxicol In Vitro. 2022 Jan 24:105321. doi: 10.1016/j.tiv.2022.105321. Online ahead of print.ABSTRACTPropofol has been documented to exhibit anti-tumor effects in cancers. However, the underlying mechanisms of its inhibition remain unclear. We conducted this study to investigate the effect of propofol on lncRNA GAS5 in glioma cells, and to probe the role of GAS5 in the anti-tumor effects of propofol. Human glioma cell line U251 were treated with propofol. Cell proliferation, migration, invasion, cell cycle and apoptosis were evaluated, and the expression of GAS5 was measured. After that, we knockdown the expression of GAS5 ...
Source: Toxicology in Vitro - January 27, 2022 Category: Toxicology Authors: Yan Cheng Lina Zheng Haiyun Wang Chenyi Yang Weiwei Zhang Source Type: research
Propofol postconditioning ameliorates hypoxia/reoxygenation induced H9c2 cell apoptosis and autophagy via upregulating forkhead transcription factors under hyperglycemia
CONCLUSION: It is concluded that propofol postconditioning attenuated H9c2 cardiac cells apoptosis and autophagy induced by H/R injury through upregulating FoxO1 and FoxO3a under hyperglycemia.PMID:34753510 | DOI:10.1186/s40779-021-00353-0
Source: Molecular Medicine - November 10, 2021 Category: Molecular Biology Authors: Rong-Hui Han He-Meng Huang Hong Han Hao Chen Fei Zeng Xiang Xie Dan-Yong Liu Yin Cai Liang-Qing Zhang Xin Liu Zheng-Yuan Xia Jing Tang Source Type: research
