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Specialty: Environmental Health
Drug: Sodium Fluoride
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Total 2 results found since Jan 2013.
Nrf2/PINK1-mediated mitophagy induction alleviates sodium fluoride-induced hepatic injury by improving mitochondrial function, oxidative stress, and inflammation
Ecotoxicol Environ Saf. 2023 Feb 13;252:114646. doi: 10.1016/j.ecoenv.2023.114646. Online ahead of print.ABSTRACTMitophagy has distinct functions, which can lead to either protection or damage of tissues. Though current evidence indicated that NaF triggers mitophagy, the role and regulation of mitophagy in sodium fluoride (NaF)-induced liver injury still remain unclear. Therefore, we exployed the cell and mouse models and confirmed that NaF treatment activates mitophagy. Knocking down PTEN-induced putative kinase protein 1 (PINK1) expression attenuated mitophagy and increased the degree of mitochondrial impairment, oxidati...
Source: Ecotoxicology and Environmental Safety - February 15, 2023 Category: Environmental Health Authors: Chao Song Aiguo Zhang Man Zhang Yuzhen Song Heping Huangfu Shuangxing Jin Yanting Sun Chunhui Zhang Dongmei Shi Jundong Wang Wei Peng Qin Luo Source Type: research
