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Caveolae may enable albumin to enter human renal glomerular endothelial cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - January 5, 2015 Category: Biochemistry Authors: Takahito Moriyama, Takashi Takei, Mitsuyo Itabashi, Keiko Uchida, Ken Tsuchiya, Kosaku Nitta Tags: Article Source Type: research

Differential Requirements of Arrestin-3 and Clathrin for Ligand-dependent and -independent Internalization of Human G Protein-coupled Receptor 40.
Abstract G protein-coupled receptor 40 (GPR40) is believed to be an attractive target to enhance insulin secretion in patients with type 2 diabetes. GPR40 has been found to couple to Gq protein, leading to activation of phospholipase C and subsequent increases in the intracellular Ca(2+) level. However, the underlying mechanisms that regulate the internalization and desensitization of GPR40 remain to be elucidated. In the present study, a construct of GPR40 fused with enhanced green fluorescent protein (EGFP) at its C-terminus was constructed for direct imaging of the localization and internalization of GPR40 by c...
Source: Cellular Signalling - July 16, 2014 Category: Cytology Authors: Qian J, Wu C, Chen X, Li X, Ying G, Jin L, Ma Q, Li G, Shi Y, Zhang G, Zhou N Tags: Cell Signal Source Type: research

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