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Drug: Morphine

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Total 25 results found since Jan 2013.

Epigenetics and Pain Research
i-Fect Used to Study ImpactsOur i-Fect siRNA, miRNA and shRNA Trasfection Kit was recently used to study the impact of G9a-specific siRNA (AGUAACGGGCAUCAAUGC) on Mu Opioid Receptors: Yuhao Zhang, Shao-Rui Chen, Geoffroy Laumet, Hong Chen and Hui-Lin Pan. Nerve Injury Diminishes Opioid Analgesia through Lysine Methyltransferase-Mediated Transcriptional Repression of µ-Opioid Receptors in Primary Sensory Neurons. First Published on February 25, 2016, doi: 10.1074/jbc.M115.711812... In some SNL rats, G9a-specific siRNA (4 µg) or the negative control siRNA was administered intrathecally. G9a-specific siRNA(AGUAACGGGCAUC...
Source: siRNA and DsiRNA Transfection Efficiency - March 24, 2016 Category: Neuroscience Tags: epigenetics Ga9 Mu Opioid Receptor inhibitor i-Fect iFect intrathecal delivery of siRNA Morphine neuropathic pain Source Type: news

Role for engagement of β‐arrestin2 by the transactivated EGFR in agonist‐specific regulation of δ receptor activation of ERK1/2
Conclusions and ImplicationsThe δ receptor‐mediated activation of ERK1/2 is via ligand‐specific transactivation of EGFR. This study adds new insights into the mechanism by which δ receptors activate ERK1/2.
Source: British Journal of Pharmacology - September 23, 2015 Category: Drugs & Pharmacology Authors: Le‐Sha Zhang, Yu‐Jun Wang, Yun‐Yue Ju, Gui‐Ying Zan, Chi Xu, Min‐Hua Hong, Yu‐Hua Wang, Zhi‐Qiang Chi, Jing‐Gen Liu Tags: RESEARCH PAPER Source Type: research

Role for engagement of β‐arrestin 2 by the transactivated EGFR in agonist‐specific regulation of δ receptor activation of ERK1/2
Conclusions and Implicationsδ Receptor‐mediated activation of ERK1/2 is via ligand‐specific transactivation of EGFR. This study gains a new insight into the mechanism by which δ receptor activates ERK1/2.
Source: British Journal of Pharmacology - July 25, 2015 Category: Drugs & Pharmacology Authors: Le‐Sha Zhang, Yu‐Jun Wang, Yun‐Yue Ju, Gui‐Ying Zan, Chi Xu, Min‐Hua Hong, Yu‐Hua Wang, Zhi‐Qiang Chi, Jing‐Gen Liu Tags: RESEARCH PAPER Source Type: research

Mu Opioid Receptor Stimulation Activates c-Jun N-Terminal Kinase 2 by Distinct Arrestin-Dependent and Independent Mechanisms.
This study resolves distinct ligand-directed mechanisms of JNK activation by mu opioid agonists and understanding ligand-directed signaling at MOR may improve opioid therapeutics. PMID: 26056051 [PubMed - as supplied by publisher]
Source: Cellular Signalling - June 5, 2015 Category: Cytology Authors: Kuhar JR, Bedini A, Melief EJ, Chiu YC, Striegel HN, Chavkin C Tags: Cell Signal Source Type: research

Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling
Heterogeneous nuclear ribonucleoprotein K (hnRNP K) binds to the promoter region of mu-opioid receptor (MOR) to regulate its transcriptional activity. How hnRNP K contributes to the analgesic effects of morphine, however, is largely unknown. We provide evidence that morphine increases hnRNP K protein expression via MOR activation in rat primary cortical neurons and HEK-293 cells expressing MORs, without increasing mRNA levels. Using the bicistronic reporter assay, we examined whether morphine-mediated accumulation of hnRNP K resulted from translational control. We identified potential internal ribosome entry site elements ...
Source: Nucleic Acids Research - November 27, 2014 Category: Research Authors: Lee, P.-T., Chao, P.-K., Ou, L.-C., Chuang, J.-Y., Lin, Y.-C., Chen, S.-C., Chang, H.-F., Law, P.-Y., Loh, H. H., Chao, Y.-S., Su, T.-P., Yeh, S.-H. Tags: Gene regulation, Chromatin and Epigenetics Source Type: research

Morphine Modulates Mouse Hippocampal Progenitor Cell Lineages by Upregulating miR‐181a Level
Abstract The mechanism by which addictive drugs such as morphine regulate adult neurogenesis remains elusive. We now demonstrate that morphine can regulate neurogenesis by control of miR‐181a and subsequent hippocampal neural progenitor cell (hNPC) lineages. In the presence of morphine, hNPCs preferentially differentiated into astrocytes, an effect blocked by the specific μ‐opioid receptor antagonist, Cys2‐Tyr3‐Orn5‐Pen7‐amide. This effect was mediated by the Prox1/Notch1 pathway as demonstrated by an increase in Notch1 level in the morphine‐ but not fentanyl‐treated hNPCs and blocked by overexpression of ...
Source: Stem Cells - October 14, 2014 Category: Stem Cells Authors: Chi Xu, Yue Zhang, Hui Zheng, Horace H. Loh, Ping‐Yee Law Tags: Tissue‐Specific Stem Cells Source Type: research

Different Mechanisms of Homologous and Heterologous μ‐Opioid Receptor Phosphorylation
Abstract The efficiency of μ‐opioid receptor (MOR) signaling is tightly regulated and ultimately limited by the coordinated phosphorylation of intracellular serine and threonine residues. Here, we review and discuss recent progress in the generation and application of phosphosite‐specific MOR antibodies, which have proved to be excellent tools for monitoring the spatial and temporal dynamics of receptor phosphorylation and dephosphorylation. Agonist‐induced phosphorylation of MOR occurs at a conserved 10 residue sequence 370TREHPSTANT379 in the receptor's carboxyl‐terminal cytoplasmic tail. Diverse opioids induce ...
Source: British Journal of Pharmacology - February 12, 2014 Category: Drugs & Pharmacology Authors: Anika Mann, Susann Illing, Elke Miess, Stefan Schulz Tags: Review Article – Opioids: New Pathways to Functional Selectivity – Special issue opioids from INRC meeting Themed Issue Source Type: research

G protein‐gated inwardly rectifying potassium (KIR3) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites
Conclusion and ImplicationsThese results demonstrate that KIR3.1 channels play a primary role in the antinociceptive effects of oxycodone, but not those of morphine, at supraspinal sites and suggest that supraspinal KIR3.1 channels are responsible for the unique analgesic profile of oxycodone.
Source: British Journal of Pharmacology - December 10, 2013 Category: Drugs & Pharmacology Authors: Atsushi Nakamura, Masahide Fujita, Hiroko Ono, Yoshie Hongo, Tomoe Kanbara, Koichi Ogawa, Yasuhide Morioka, Atsushi Nishiyori, Masahiro Shibasaki, Tomohisa Mori, Tsutomu Suzuki, Gaku Sakaguchi, Akira Kato, Minoru Hasegawa Tags: RESEARCH PAPER Source Type: research

Heterologous Regulation of Agonist‐Independent μ‐Opioid Receptor Phosphorylation by Protein Kinase C
Conclusions & ImplicationsThe present results unravel novel mechanisms of heterologous regulation of MOR phosphorylation by PKC. These findings represent a useful starting point for definitive experiments elucidating the exact contribution of PKC‐driven MOR phosphorylation to diminished MOR responsiveness in morphine tolerance and pathological pain.
Source: British Journal of Pharmacology - December 6, 2013 Category: Drugs & Pharmacology Authors: Susann Illing, Anika Mann, Stefan Schulz Tags: Research Paper Source Type: research

G protein‐gated inwardly rectifying potassium (GIRK) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites
Conclusion and ImplicationsThe results demonstrated that GIRK1 channels play a primary role in the antinociceptive effects of oxycodone, but not morphine, at supraspinal sites, and suggested that supraspinal GIRK1 channels are responsible for the unique analgesic profile of oxycodone.
Source: British Journal of Pharmacology - October 7, 2013 Category: Drugs & Pharmacology Authors: Atsushi Nakamura, Masahide Fujita, Hiroko Ono, Yoshie Hongo, Tomoe Kanbara, Koichi Ogawa, Yasuhide Morioka, Atsushi Nishiyori, Masahiro Shibasaki, Tomohisa Mori, Tsutomu Suzuki, Gaku Sakaguchi, Akira Kato, Minoru Hasegawa Tags: Research Paper Source Type: research