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Drug: Metformin
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Total 2 results found since Jan 2013.

Hyperglycaemia aggravates periodontal inflamm-aging by promoting SETDB1-mediated LINE-1 de-repression in macrophages
CONCLUSIONS: The findings of this study show that SETDB1 regulates senescence-like phenotypical switching of macrophages and is a potential candidate for the treatment of diabetes-induced periodontal inflamm-aging.PMID:37661095 | DOI:10.1111/jcpe.13871
Source: Journal of Clinical Periodontology - September 3, 2023 Category: Dentistry Authors: Ziqi Yue Luningxiao Nie Ning Ji Yuezhang Sun Kangjian Zhu Haonan Zou Xiuxiu Song Jiao Chen Qi Wang Source Type: research

Metformin Promotes 2-Deoxy-2- 18 FFluoro-D-Glucose Uptake in Hepatocellular Carcinoma Cells Through FoxO1-Mediated Downregulation of Glucose-6-Phosphatase
ConclusionsWe propose that treatment of HCC cells with Met may be a useful strategy for improving the efficacy of [18F]FDG as a tracer for PET/CT imaging of HCC tumors in patients.
Source: Molecular Imaging and Biology - December 18, 2017 Category: Molecular Biology Source Type: research