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Vitamin D-induced ectodomain shedding of TNF receptor 1 as a nongenomic action: D3 vs D2 derivatives
In this study, we examined the potencies of other vitamin D3 and D2 analogs to stimulate the ectodomain shedding of TNFR1 in HASMCs. 25-Hydroxyvitamin D3 (25D3), a precursor of 1,25D3, and elocalcitol, an analog of 1,25D3, caused ectodomain shedding of TNFR1 within 30min, whereas 1,25-dihydroxyvitamin D2 (1,25D2) and paricalcitol, a derivative of 1,25D2, did not. Both 25D3 and elocalcitol rapidly induced extracellular Ca2+ influx and markedly increased intracellular Ca2+, while 1,25D2 and paricalcitol caused only small increases in intracellular Ca2+. 25D3- and elocalcitol-induced TNFR1 ectodomain sheddings were abolished ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - September 30, 2015 Category: Biochemistry Source Type: research

Title: Vitamin D-induced ectodomain shedding of TNF receptor 1 as a nongenomic action: D3 vs D2 derivatives
In this study, we examined the potencies of other vitamin D3 and D2 analogs to stimulate the ectodomain shedding of TNFR1 in HASMCs. 25-Hydroxyvitamin D3 (25D3), a precursor of 1,25D3, and elocalcitol, an analog of 1,25D3, caused ectodomain shedding of TNFR1 within 30min, whereas 1,25-dihydroxyvitamin D2 (1,25D2) and paricalcitol, a derivative of 1,25D2, did not. Both 25D3 and elocalcitol rapidly induced extracellular Ca2+ influx and markedly increased intracellular Ca2+, while 1,25D2 and paricalcitol caused only small increases in intracellular Ca2+. 25D3- and elocalcitol-induced TNFR1 ectodomain sheddings were abolished ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - September 16, 2015 Category: Biochemistry Source Type: research