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GNB2 is a mediator of lidocaine-induced apoptosis in rat pheochromocytoma PC12 cells.
Abstract Lidocaine has been recognized to induce neurotoxicity. However, the molecular mechanism underlying this effect, especially the critical molecules in cells that mediated the lidocaine-induced apoptosis were unclear. In the present study, PC12 cells were administrated with lidocaine for 48h. Using MTT assay and flow cytometry, we found lidocaine significantly decreased the cell proliferation and S phases in PC12 cells with treatment concentrations, and significantly enhanced cell apoptosis with treatment concentrations. Two-dimensional gel electrophoresis (2-DE) analysis and LC-MS/MS were used to identifica...
Source: Neurotoxicology - March 22, 2016 Category: Neurology Authors: Tan Y, Wang Q, Zhao B, She Y, Bi X Tags: Neurotoxicology Source Type: research