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Drug: Gleevec
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Total 75 results found since Jan 2013.
SPHINX-Based Combination Therapy as a Potential Novel Treatment Strategy for Acute Myeloid Leukaemia
Conclusion: We suggest that specific types of leukaemia may present an opportunity for the development of SRPK1-targeted therapies to be used in combination with established chemotherapeutic drugs.PMID:36895328 | PMC:PMC9988938 | DOI:10.3389/bjbs.2023.11041
Source: British Journal of Biomedical Science - March 10, 2023 Category: Laboratory Medicine Authors: Chigeru Wodi Tareg Belali Ruth Morse Sean Porazinski Michael Ladomery Source Type: research
Hypoxia inducible factor 1 α inhibitor induces cell death via suppression of BCR-ABL1 and Met expression in BCR-ABL1 tyrosine kinase inhibitor sensitive and resistant chronic myeloid leukemia cells
In this study, we examined whether HIF-1α inhibitors induce cell death in CML cells and BCR-ABL1 TKI-resistant CML cells. We found that echinomycin and PX-478 induced cell death in BCR-ABL1 TKIs sensitive and resistant CML cells at similar concentrations while the cell sensitivity was not affected with imatinib or dasatinib in BCR-ABL1 TKIs resistant CML cells. In addition, echinomycin and PX-478 inhibited the c-Jun N-terminal kinase (JNK), Akt, and extracellular-regulated protein kinase 1/2 (ERK1/2) activation via suppression of BCR-ABL1 and Met expression in BCR-ABL1 sensitive and resistant CML cells. Moreover, treatmen...
Source: BMB Reports - October 4, 2022 Category: Biochemistry Authors: Masanobu Tsubaki Tomoya Takeda Takuya Matsuda Akihiro Kimura Remi Tanaka Sakiko Nagayoshi Tadafumi Hoshida Kazufumi Tanabe Shozo Nishida Source Type: research
