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Increased mitochondrial fission induces NLRP3/cGAS-STING mediated pro-inflammatory pathways and apoptosis in UVB-irradiated immortalized human keratinocyte HaCaT cells
Arch Biochem Biophys. 2023 Mar 5;738:109558. doi: 10.1016/j.abb.2023.109558. Online ahead of print.ABSTRACTUltraviolet B (UVB) irradiation causes skin inflammation and apoptosis. Mitochondria are highly dynamic and undergo constant fusion and fission that are essential for maintaining physiological functions of cells. Although dysfunction of mitochondria has been implicated in skin damages, little is known about the roles of mitochondrial dynamics in these processes. UVB irradiation increases abnormal mitochondrial content but decreases mitochondrial volume in immortalized human keratinocyte HaCaT cells. UVB irradiation re...
Source: Archives of Biochemistry and Biophysics - March 6, 2023 Category: Biochemistry Authors: Can Li Yuying Zhu Weiwei Liu Toshihiko Hayashi Wendie Xiang Sijun He Kazunori Mizuno Shunji Hattori Hitomi Fujisaki Takashi Ikejima Source Type: research

Nickel-refining fumes induce NLRP3 activation dependent on mitochondrial damage and ROS production in Beas-2B cells.
Abstract Nickel (Ni) is a silver-white transition metal that is widely used in the production field due to its unique physical and chemical properties. As a toxicant, long-term exposure to Ni can cause rhinitis, pneumonia and other respiratory inflammation. In the present study, we investigated the effect of particles extracted from Ni-refining fumes on cell viability, inflammation-related proteins and mitochondrial damage in human lung epithelial Beas-2B cells. The cells were exposed to Ni-refining fume particles for 24 h at concentrations of 0, 6.25, 12.50 and 25.00 μg/mL. The expression levels of the NAC...
Source: Archives of Biochemistry and Biophysics - October 9, 2019 Category: Biochemistry Authors: Xin R, Pan YL, Wang Y, Wang SY, Wang R, Xia B, Qin RN, Fu Y, Wu YH Tags: Arch Biochem Biophys Source Type: research