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ABL1 and Cofilin1 promote T-cell acute lymphoblastic leukemia cell migration
Acta Biochim Biophys Sin (Shanghai). 2021 Sep 11:gmab117. doi: 10.1093/abbs/gmab117. Online ahead of print.ABSTRACTThe fusion gene of ABL1 is closely related to tumor proliferation, invasion, and migration. It has been reported recently that ABL1 itself is required for T-cell acute lymphoblastic leukemia (T-ALL) cell migration induced by CXCL12. Further experiments revealed that ABL1 inhibitor Nilotinib inhibited leukemia cell migration induced by CXCL12, indicating the possible application of Nilotinib in T-ALL leukemia treatment. However, the interacting proteins of ABL1 and the specific mechanisms of their involvement i...
Source: Acta Biochimica et Biophysica Sinica - September 11, 2021 Category: Biochemistry Authors: Jixian Luo Huiguang Zheng Sen Wang Dingyun Li Wenli Ma Lan Wang M James C Crabbe Source Type: research

c-Abl phosphorylation of Yin Yang 1's conserved tyrosine 254 in the spacer region modulates its transcriptional activity.
In conclusion, we demonstrate the novel role of c-Abl kinase in regulation of YY1's transcriptional activity, linking YY1 regulation with c-Abl tyrosine kinase signaling pathways. PMID: 29807053 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - May 25, 2018 Category: Biochemistry Authors: Daraiseh SI, Kassardjian A, Alexander KE, Rizkallah R, Hurt MM Tags: Biochim Biophys Acta Source Type: research