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In Situ Functionalized Polymers for siRNA Delivery.
Abstract A new method is reported herein for screening the biological activity of functional polymers across a consistent degree of polymerization and in situ, that is, under aqueous conditions and without purification/isolation of candidate polymers. In brief, the chemical functionality of a poly(acryloyl hydrazide) scaffold was activated under aqueous conditions using readily available aldehydes to obtain amphiphilic polymers. The transport activity of the resulting polymers can be evaluated in situ using model membranes and living cells without the need for tedious isolation and purification steps. This tec...
Source: Angewandte Chemie - April 20, 2016 Category: Chemistry Authors: Priegue JM, Crisan DN, Martínez-Costas J, Granja JR, Fernandez-Trillo F, Montenegro J Tags: Angew Chem Int Ed Engl Source Type: research

Dynamic Amphiphile Libraries To Screen for the “Fragrant” Delivery of siRNA into HeLa Cells and Human Primary Fibroblasts
Journal of the American Chemical SocietyDOI: 10.1021/ja404153m
Source: Journal of the American Chemical Society - June 14, 2013 Category: Chemistry Authors: Charlotte Gehin, Javier Montenegro, Eun-Kyoung Bang, Ana Cajaraville, Shota Takayama, Hisaaki Hirose, Shiroh Futaki, Stefan Matile and Howard Riezman Source Type: research