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Effects of Type 1 Insulin-Like Growth Factor Receptor Silencing in a Human Adrenocortical Cell Line
Horm Metab ResDOI: 10.1055/s-0042-108196Type 1 insulin-like growth factor receptor (IGF-1R) is overexpressed in a variety of human cancers, including adrenocortical tumors. The aim of the work was to investigate the effects of IGF-1R downregulation in a human adrenocortical cell line by small interfering RNA (siRNA). The human adrenocortical tumor cell line NCI H295R was transfected with 2 specific IGF1R siRNAs (# 1 and # 2) and compared with untreated cells and a negative control siRNA. IGF1R expression was determined by quantitative reverse-transcription PCR (qRTPCR) and Western blot. The effects of IGF-1R downregulation...
Source: Hormone and Metabolic Research - May 30, 2016 Category: Endocrinology Authors: Ribeiro, T. C.Jorge, A. A.Montenegro, L. R.Almeida, M. Q.Ferraz-de-Souza, B.Nishi, M. Y.Mendonca, B. B.Latronico, A. C. Tags: Endocrine Research Source Type: research