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Cancers, Vol. 11, Pages 123: PKA at a Cross-Road of Signaling Pathways Involved in the Regulation of Glioblastoma Migration and Invasion by the Neuropeptides VIP and PACAP
-Marc Muller Glioblastoma (GBM) remains an incurable disease, mainly due to the high migration and invasion potency of GBM cells inside the brain. PI3K/Akt, Sonic Hedgehog (SHH), and PKA pathways play major regulatory roles in the progression of GBM. The vasoactive intestinal peptide (VIP) family of neuropeptides and their receptors, referred in this article as the “VIP-receptor system”, has been reported to regulate proliferation, differentiation, and migration in a number of tumor cell types and more particularly in GBM cells. These neuropeptides are potent activators of the cAMP/PKA pathw...
Source: Cancers - January 21, 2019 Category: Cancer & Oncology Authors: Souheyla Bensalma Soumaya Turpault Annie-Claire Balandre Madryssa De Boisvilliers Afsaneh Gaillard Corinne Chad éneau Jean-Marc Muller Tags: Article Source Type: research

Abstract P3-05-13: Overexpression of insulin receptor substrate 4 can mediate acquired resistance to lapatinib-containing regimens in HER2+ breast cancer cells
Conclusion: IRS4 overexpression is a critical factor in causing resistance to lapatinib-containing regimens in BT474 cells. Investigation of IRS4 and its signaling partners in HER2+ human tumors resistant to lapatinib will be important to determine if this mechanism is also operative in patients. Citation Format: Lanfang Qin, Maria B Hahn, Xiaoyong Fu, Martin J Shea, Mario Giuliano, Sarmistha Nanda, Xiaowei Xu, Huizhong Hu, Sung Yun Jung, Laura M Heiser, Nicholas Wang, Joe W Gray, Susan G Hilsenbeck, Chad Creighton, Chad A Shaw, Gary C Chamness, Dean P Edwards, Sabrina Herrera, Carolina Gutierrez, C Kent Osborne, Rachel Sc...
Source: Cancer Research - April 30, 2015 Category: Cancer & Oncology Authors: Qin, L., Hahn, M. B., Fu, X., Shea, M. J., Giuliano, M., Nanda, S., Xu, X., Hu, H., Jung, S. Y., Heiser, L. M., Wang, N., Gray, J. W., Hilsenbeck, S. G., Creighton, C., Shaw, C. A., Chamness, G. C., Edwards, D. P., Herrera, S., Gutierrez, C., Osborne, C. Tags: Poster Session Abstracts Source Type: research