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Total 8 results found since Jan 2013.
ASAP Hairpin-like siRNA-Based Spherical Nucleic Acids
Journal of the American Chemical SocietyDOI: 10.1021/jacs.1c12750
Source: Journal of the American Chemical Society - February 10, 2022 Category: Chemistry Authors: Matthew K. Vasher, Gokay Yamankurt, and Chad A. Mirkin Source Type: research
Advancement of PI3 Kinase Inhibitor Combination Therapies for PI3K-Aberrant Chordoma
Conclusion High throughput with in vitro combination screening is feasible with chordoma cells and allows for rapid identification of synergistic dual-therapies. Potential combination therapies and targetable pathways were identified. T (brachyury) knockdown produced significant reduction in cell viability, but did not show additional benefit with PI3K pathway inhibition in this model. Further in vitro and in vivo validation of these therapeutic combinations is warranted. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Journal of Neurological Surgery Part B: Skull Base - October 12, 2020 Category: Neurosurgery Authors: Heft Neal, Molly E. Michmerhuizen, Nicole L. Kovatch, Kevin J. Owen, John Henry J. Zhai, Jingyi Jiang, Hui McKean, Erin L. Prince, Mark E.P. Brenner, J. Chad Tags: Original Article Source Type: research
The effector mechanism of siRNA spherical nucleic acids Biochemistry
Spherical nucleic acids (SNAs) are nanostructures formed by chemically conjugating short linear strands of oligonucleotides to a nanoparticle template. When made with modified small interfering RNA (siRNA) duplexes, SNAs act as single-entity transfection and gene silencing agents and have been used as lead therapeutic constructs in several disease models. However,...
Source: Proceedings of the National Academy of Sciences - January 20, 2020 Category: Science Authors: Gokay Yamankurt, Robert J. Stawicki, Diana M. Posadas, Joseph Q. Nguyen, Richard W. Carthew, Chad A. Mirkin Tags: Physical Sciences Source Type: research
Cancers, Vol. 11, Pages 123: PKA at a Cross-Road of Signaling Pathways Involved in the Regulation of Glioblastoma Migration and Invasion by the Neuropeptides VIP and PACAP
-Marc Muller
Glioblastoma (GBM) remains an incurable disease, mainly due to the high migration and invasion potency of GBM cells inside the brain. PI3K/Akt, Sonic Hedgehog (SHH), and PKA pathways play major regulatory roles in the progression of GBM. The vasoactive intestinal peptide (VIP) family of neuropeptides and their receptors, referred in this article as the “VIP-receptor system”, has been reported to regulate proliferation, differentiation, and migration in a number of tumor cell types and more particularly in GBM cells. These neuropeptides are potent activators of the cAMP/PKA pathw...
Source: Cancers - January 21, 2019 Category: Cancer & Oncology Authors: Souheyla Bensalma Soumaya Turpault Annie-Claire Balandre Madryssa De Boisvilliers Afsaneh Gaillard Corinne Chad éneau Jean-Marc Muller Tags: Article Source Type: research
siRNA rescues nonhuman primates from advanced Marburg and Ravn virus disease
Ebolaviruses and marburgviruses belong to the family Filoviridae and cause high lethality in infected patients. There are currently no licensed filovirus vaccines or antiviral therapies. The development of broad-spectrum therapies against members of the Marburgvirus genus, including Marburg virus (MARV) and Ravn virus (RAVV), is difficult because of substantial sequence variability. RNAi therapeutics offer a potential solution, as identification of conserved target nucleotide sequences may confer activity across marburgvirus variants. Here, we assessed the therapeutic efficacy of lipid nanoparticle (LNP) delivery of a sing...
Source: Journal of Clinical Investigation - November 7, 2017 Category: Biomedical Science Authors: Emily P. Thi, Chad E. Mire, Amy C.H. Lee, Joan B. Geisbert, Raul Ursic-Bedoya, Krystle N. Agans, Marjorie Robbins, Daniel J. Deer, Robert W. Cross, Andrew S. Kondratowicz, Karla A. Fenton, Ian MacLachlan, Thomas W. Geisbert Source Type: research
Abstract P3-05-13: Overexpression of insulin receptor substrate 4 can mediate acquired resistance to lapatinib-containing regimens in HER2+ breast cancer cells
Conclusion: IRS4 overexpression is a critical factor in causing resistance to lapatinib-containing regimens in BT474 cells. Investigation of IRS4 and its signaling partners in HER2+ human tumors resistant to lapatinib will be important to determine if this mechanism is also operative in patients.
Citation Format: Lanfang Qin, Maria B Hahn, Xiaoyong Fu, Martin J Shea, Mario Giuliano, Sarmistha Nanda, Xiaowei Xu, Huizhong Hu, Sung Yun Jung, Laura M Heiser, Nicholas Wang, Joe W Gray, Susan G Hilsenbeck, Chad Creighton, Chad A Shaw, Gary C Chamness, Dean P Edwards, Sabrina Herrera, Carolina Gutierrez, C Kent Osborne, Rachel Sc...
Source: Cancer Research - April 30, 2015 Category: Cancer & Oncology Authors: Qin, L., Hahn, M. B., Fu, X., Shea, M. J., Giuliano, M., Nanda, S., Xu, X., Hu, H., Jung, S. Y., Heiser, L. M., Wang, N., Gray, J. W., Hilsenbeck, S. G., Creighton, C., Shaw, C. A., Chamness, G. C., Edwards, D. P., Herrera, S., Gutierrez, C., Osborne, C. Tags: Poster Session Abstracts Source Type: research
MYC Is an Early Response Regulator of Human Adipogenesis in Adipose Stem Cells
by Chad Deisenroth, Michael B. Black, Salil Pendse, Linda Pluta, Sam M. Witherspoon, Patrick D. McMullen, Russell S. Thomas
Adipose stem cell (ASC) differentiation is necessary for the proper maintenance and function of adipose tissue. The procurement and characterization of multipotent ASCs has enabled investigation into the molecular determinants driving human adipogenesis. Here, the transcription factor MYC was identified as a significant regulator of ASC differentiation. Expression of MYC transcript and protein was found to accumulate during the initial course of differentiation. Loss-of-function analysis using siRNA ...
Source: PLoS One - December 1, 2014 Category: Biomedical Science Authors: Chad Deisenroth et al. Source Type: research
HRAS mutations and resistance to the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in head and neck squamous cell carcinoma cells
Conclusion: Activating HRAS mutations can confer erlotinib resistance in an HRAS mutant HNSCC cell line. Head Neck, 2013.
Source: Head and Neck - September 30, 2013 Category: ENT & OMF Authors: J. Hun Hah, Mei Zhao, Curtis R. Pickering, Mitchell J. Frederick, Genevieve A. Andrews, Samar A. Jasser, David R. Fooshee, Zvonimir L. Milas, Chad Galer, Daisuke Sano, William N. William, Edward Kim, John Heymach, Lauren A. Byers, Vali Papadimitrakopoulou Tags: Research Article Source Type: research
