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Advancement of PI3 Kinase Inhibitor Combination Therapies for PI3K-Aberrant Chordoma
Conclusion High throughput with in vitro combination screening is feasible with chordoma cells and allows for rapid identification of synergistic dual-therapies. Potential combination therapies and targetable pathways were identified. T (brachyury) knockdown produced significant reduction in cell viability, but did not show additional benefit with PI3K pathway inhibition in this model. Further in vitro and in vivo validation of these therapeutic combinations is warranted. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Journal of Neurological Surgery Part B: Skull Base - October 12, 2020 Category: Neurosurgery Authors: Heft Neal, Molly E. Michmerhuizen, Nicole L. Kovatch, Kevin J. Owen, John Henry J. Zhai, Jingyi Jiang, Hui McKean, Erin L. Prince, Mark E.P. Brenner, J. Chad Tags: Original Article Source Type: research

Cancers, Vol. 11, Pages 123: PKA at a Cross-Road of Signaling Pathways Involved in the Regulation of Glioblastoma Migration and Invasion by the Neuropeptides VIP and PACAP
-Marc Muller Glioblastoma (GBM) remains an incurable disease, mainly due to the high migration and invasion potency of GBM cells inside the brain. PI3K/Akt, Sonic Hedgehog (SHH), and PKA pathways play major regulatory roles in the progression of GBM. The vasoactive intestinal peptide (VIP) family of neuropeptides and their receptors, referred in this article as the “VIP-receptor system”, has been reported to regulate proliferation, differentiation, and migration in a number of tumor cell types and more particularly in GBM cells. These neuropeptides are potent activators of the cAMP/PKA pathw...
Source: Cancers - January 21, 2019 Category: Cancer & Oncology Authors: Souheyla Bensalma Soumaya Turpault Annie-Claire Balandre Madryssa De Boisvilliers Afsaneh Gaillard Corinne Chad éneau Jean-Marc Muller Tags: Article Source Type: research