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Pepsin exposure in a non ‐acidic environment upregulates mucin 5AC (MUC5AC) expression via matrix metalloproteinase 9 (MMP9)/nuclear factor κB (NF‐κB) in human airway epithelial cells
ConclusionThese findings suggest that pepsin increased MUC5AC expression in non ‐acidic conditions via the activation of MMP9 and NF‐κB in human airway epithelial cells.
Source: International Forum of Allergy and Rhinology - April 21, 2021 Category: Allergy & Immunology Authors: Yoon Seok Choi, Hyung Gyun Na, Chang Hoon Bae, Si ‐Youn Song, Yong‐Dae Kim Tags: ORIGINAL ARTICLE Source Type: research

Cigarette smoke extract inhibits cell migration and contraction via the reactive oxygen species/adenosine monophosphate –activated protein kinase pathway in nasal fibroblasts
ConclusionCSE has an inhibitory effect on cell migration and collagen gel contraction activity via the ROS/AMPK signaling pathway in nasal fibroblasts.
Source: International Forum of Allergy and Rhinology - November 5, 2019 Category: Allergy & Immunology Authors: Jae ‐Min Shin, Joo‐Hoo Park, Hyun‐Woo Yang, Heung‐Man Lee, Il‐Ho Park Tags: ORIGINAL ARTICLE Source Type: research

Escherichia coli –derived and Staphylococcus aureus–derived extracellular vesicles induce MUC5AC expression via extracellular signal related kinase 1/2 and p38 mitogen‐activated protein kinase in human airway epithelial cells
ConclusionThe results of this study suggest that E. coli–derived and S. aureus–derived EVs induced MUC5AC expression via ERK1/2 and p38 MAPK signaling pathways in human airway epithelial cells.
Source: International Forum of Allergy and Rhinology - August 31, 2016 Category: Allergy & Immunology Authors: Chang Hoon Bae, Yoon Seok Choi, Si ‐Youn Song, Yoon‐Keun Kim, Yong‐Dae Kim Tags: ORIGINAL ARTICLE Source Type: research

Cadmium induces mucin 8 expression via Toll‐like receptor 4–mediated extracellular signal related kinase 1/2 and p38 mitogen‐activated protein kinase in human airway epithelial cells
ConclusionThe results of this study suggest for the first time that cadmium induces MUC8 expression via TLR4‐mediated ERK1/2 and p38 MAPK signaling pathway in human airway epithelial cells.
Source: International Forum of Allergy and Rhinology - January 1, 2016 Category: Allergy & Immunology Authors: Si‐Youn Song, Chang Hoon Bae, Yoon Seok Choi, Yong‐Dae Kim Tags: ORIGINAL ARTICLE Source Type: research

Effect of β‐glucan on MUC4 and MUC5B expression in human airway epithelial cells
ConclusionThese results demonstrate that in human airway epithelial cells β‐glucan induces MUC4 and MUC5B expression via the TLR4–p38 MAPK–NF‐κB signaling pathway.
Source: International Forum of Allergy and Rhinology - May 1, 2015 Category: Allergy & Immunology Authors: Yong‐Dae Kim, Chang Hoon Bae, Si‐Youn Song, Yoon Seok Choi Tags: ORIGINAL ARTICLE Source Type: research