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A hormone-dependent feedback-loop controls androgen receptor levels by limiting MID1, a novel translation enhancer and promoter of oncogenic signaling
Conclusion: Promotion of AR, in addition to enhancement of the Akt-, NFkappaB-, and Hh-pathways by sustained MID1-upregulation during androgen deprivation therapy provides a powerful proliferative scenario for PCa progression into castration resistance. Thus MID1 represents a novel, multi-faceted player in PCa and a promising target to treat castration resistant prostate cancer.
Source: Molecular Cancer - June 9, 2014 Category: Cancer & Oncology Authors: Andrea KöhlerÜmmühan DemirEva KicksteinSybille KraussJohanna AignerBeatriz Aranda-OrgillésAntonios KaragiannidisClemens AchmüllerHuajie BuAndrea WunderlichMichal-Ruth SchweigerGeorg SchaeferSusann SchweigerHelmut KlockerRainer Schneider Source Type: research

cAMP signaling inhibits radiation-induced ATM phosphorylation leading to the augmentation of apoptosis in human lung cancer cells
Conclusions: cAMP signaling inhibits radiation-induced ATM activation by PKA-dependent activation of PP2A, and this signaling mechanism augments radiation-induced apoptosis by reducing ATM-dependent activation of NF-kappaB in lung cancer cells.
Source: Molecular Cancer - February 24, 2014 Category: Cancer & Oncology Authors: Eun-Ah ChoEui-Jun KimSahng-June KwakYong-Sung Juhnn Source Type: research