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Abnormal Downregulation of Caveolin-3 Mediates the Pro-Fibrotic Action of MicroRNA-22 in a Model of Myocardial Infarction
Conclusions: Our findings demonstrate that miR-22 accelerates cardiac fibrosis through the miR-22-Cav3-PKC ε pathway, which, therefore, may represent a new therapeutic target for treatment of excessive fibrosis-associated cardiac diseases.Cell Physiol Biochem 2018;45:1641 –1653
Source: Cellular Physiology and Biochemistry - February 27, 2018 Category: Cytology Source Type: research

Downregulation of Long Non-Coding RNA Kcnq1ot1: An Important Mechanism of Arsenic Trioxide-Induced Long QT Syndrome
Conclusions: To our knowledge, this report is the first to demonstrate that lncRNAKcnq1ot1 downregulation is responsible for QT interval prolongation induced by ATO at least partially by repressingKcnq1 expression. lncRNAKcnq1ot1 has important pathophysiological functions in the heart and could become a novel antiarrhythmic target.Cell Physiol Biochem 2018;45:192 –202
Source: Cellular Physiology and Biochemistry - January 16, 2018 Category: Cytology Source Type: research