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The X box binding protein 1/C/EBP homologous protein pathway induces apoptosis of endothelial cells under hyperglycemia
Exp Ther Med. 2022 May 18;24(1):454. doi: 10.3892/etm.2022.11381. eCollection 2022 Jul.ABSTRACTVenous endothelial cell apoptosis can be induced by endoplasmic reticulum (ER) stress, thus serving an important role in the formation of deep venous thrombosis. X-box binding protein 1 (XBP1) is a protein associated with ER. The present study aimed to explore the function of XBP1/C/EBP homologous protein (CHOP) pathway in the process of endothelial cell apoptosis under hyperglycemia. Small interfering (si)RNAs targeting XBP1 and CHOP were designed to downregulate the expression of XBP1 and CHOP in human umbilical vein endothelia...
Source: Experimental and Therapeutic Medicine - June 20, 2022 Category: General Medicine Authors: Maoshun Tang Yi Zheng Jianping Li Yuanlang Hu Source Type: research

Roles of microRNA-186 and vascular endothelial growth factor in hepatocellular carcinoma complicated with portal vein tumor thrombus.
In conclusion, VEGF was significantly increased in tumor thrombus and blood samples from HCC patients with vein tumor thrombus, which may be associated with the downregulation of miR-186. Thus, miR-186 may promote the development and progression of vein tumor thrombus in HCC. PMID: 32855736 [PubMed]
Source: Experimental and Therapeutic Medicine - August 30, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research