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Condition: ALS
Drug: Lithium
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Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate
Publication date: 20 August 2015 Source:Neuroscience, Volume 301 Author(s): S.-Y. Wang , M. Ren , H.-Z. Jiang , J. Wang , H.-Q. Jiang , X. Yin , Y. Qi , X.-D. Wang , G.-T. Dong , T.-H. Wang , Y.-Q. Yang , H.-L. Feng Amyotrophic lateral sclerosis (ALS) is an idiopathic and lethal neurodegenerative disease that currently has no effective treatment. A recent study found that the Notch signaling pathway was up-regulated in a TAR DNA-binding protein-43 (TDP-43) Drosophila model of ALS. Notch signaling acts as a master regulator in the central nervous system. However, the mechanisms by which Notch participates in the pathogene...
Source: Neuroscience - June 26, 2015 Category: Neuroscience Source Type: research
