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Condition: ALS
Drug: Carisoprodol
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Total 1 results found since Jan 2013.
Functional Interaction between Amyloid-β Precursor Protein and Peripherin Neurofilaments: A Shared Pathway Leading to Alzheimer's Disease and Amyotrophic Lateral Sclerosis?
Conclusion: Our results indicate that a fraction of APP is cleaved by β-secretase in the soma and that the generated sAPP becomes associated with perinuclear peripherin neurofilaments. These findings link the metabolism of APP - which is dysregulated in AD - to the organization of neurofilaments - which is abnormal in ALS - and suggest a possible crosstalk/overlap between the molecular mechanisms of these diseases.
PMID: 24009040 [PubMed - as supplied by publisher]
Source: Neuro-Degenerative Diseases - September 4, 2013 Category: Neurology Authors: Muresan V, Villegas C, Ladescu Muresan Z Tags: Neurodegener Dis Source Type: research
