• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

The RIPK3 Scaffold Regulates Lung Inflammation During Pseudomonas Aeruginosa Pneumonia
Am J Respir Cell Mol Biol. 2022 Sep 30. doi: 10.1165/rcmb.2021-0474OC. Online ahead of print.ABSTRACTRIPK3 kinase activity triggers cell death via necroptosis, while scaffold function supports protein binding and cytokine production. To determine if RIPK3 kinase or scaffold domains mediate pathology during Pseudomonas aeruginosa infection, control mice and those with deletion or mutation of RIPK3 and associated signaling partners were subjected to Pseudomonas pneumonia and followed for survival or sacrificed for biologic assays. Murine immune cells were studied in vitro for Pseudomonas-induced cytokine production and cell ...
Source: American Journal of Respiratory Cell and Molecular Biology - September 30, 2022 Category: Molecular Biology Authors: John D Lyons Pratyusha Mandal Shunsuke Otani Deena B Chihade Kristen F Easley David A Swift Eileen M Burd Zhe Liang Michael Koval Edward S Mocarski Craig M Coopersmith Source Type: research

Pneumococci LytA-dependent KLF4 Expression Terminates IL-8 Secretion in Lung Epithelium.
In conclusion, KLF4 acts as a counter-regulatory transcription factor in pneumococci-related pro-inflammatory activation of lung epithelial cells, thereby potentially preventing lung hyper-inflammation and subsequent organ failure. PMID: 25756955 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory Cell and Molecular Biology - March 10, 2015 Category: Molecular Biology Authors: Zahlten J, Herta T, Kabus C, Steinfeldt M, Kershaw O, García P, Hocke AC, Gruber AD, Hübner RH, Steinicke R, Doehn JM, Suttorp N, Hippenstiel S Tags: Am J Respir Cell Mol Biol Source Type: research