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1,25(OH) < sub > 2 < /sub > D < sub > 3 < /sub > promotes the elimination of Klebsiella pneumoniae infection by inducing autophagy through the VDR-ATG16L1 pathway
CONCLUSIONS: The present study demonstrated the protective features of 1,25(OH)2D3 in macrophages against Kp infection and may provide evidence for further exploration of its potential as an adjunctive therapy agent for the treatment of bacterial infections.PMID:36174418 | DOI:10.1016/j.intimp.2022.109266
Source: International Immunopharmacology - September 29, 2022 Category: Allergy & Immunology Authors: Jinhui Tang Liwen Gu Jieyu Luo Haihua Luo Qingli Zeng Yong Jiang Source Type: research

Linalool attenuates lung inflammation induced by Pasteurella multocida via activating Nrf-2 signaling pathway.
In this study, linalool, a natural compound of the essential oils in several aromatic plant species, elevated nuclear Nrf-2 protein translocation in the A549 lung cell line and in vivo. The P. multocida-induced pro-inflammatory cytokines expression was abrogated by Nrf-2 siRNA. Postponed treatment with linalool decreased lung neutrophil accumulation and enhanced clearance of P. multocida. Furthermore, linalool significantly increased the expression of antioxidant enzymes regulated by Nrf-2 and diminished lung tissue levels of several pro-inflammatory cytokines, including tumor necrosis factor α (TNF-α) and interleukin (I...
Source: International Immunopharmacology - June 9, 2014 Category: Allergy & Immunology Authors: Wu Q, Yu L, Qiu J, Shen B, Wang D, Soromou LW, Feng H Tags: Int Immunopharmacol Source Type: research