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Source: Mol Biol Cell
Condition: Pneumonia
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Total 2 results found since Jan 2013.
The RIPK3 Scaffold Regulates Lung Inflammation During Pseudomonas Aeruginosa Pneumonia
Am J Respir Cell Mol Biol. 2022 Sep 30. doi: 10.1165/rcmb.2021-0474OC. Online ahead of print.ABSTRACTRIPK3 kinase activity triggers cell death via necroptosis, while scaffold function supports protein binding and cytokine production. To determine if RIPK3 kinase or scaffold domains mediate pathology during Pseudomonas aeruginosa infection, control mice and those with deletion or mutation of RIPK3 and associated signaling partners were subjected to Pseudomonas pneumonia and followed for survival or sacrificed for biologic assays. Murine immune cells were studied in vitro for Pseudomonas-induced cytokine production and cell ...
Source: Mol Biol Cell - September 30, 2022 Category: Molecular Biology Authors: John D Lyons Pratyusha Mandal Shunsuke Otani Deena B Chihade Kristen F Easley David A Swift Eileen M Burd Zhe Liang Michael Koval Edward S Mocarski Craig M Coopersmith Source Type: research
