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Harmine targets inhibitor of DNA binding-2 and activator protein-1 to promote preosteoclast PDGF-BB production
In conclusion, our data demonstrated a novel mechanism involving in the production of PDGF-BB increased by harmine, which may provide potential therapeutic targets for bone loss diseases.PMID:33960660 | DOI:10.1111/jcmm.16562
Source: J Cell Mol Med - May 7, 2021 Category: Molecular Biology Authors: Jie Huang You-You Li Kun Xia Yi-Yi Wang Chun-Yuan Chen Meng-Lu Chen Jia Cao Zheng-Zhao Liu Zhen-Xing Wang Hao Yin Xiong-Ke Hu Zheng-Guang Wang Yong Zhou Hui Xie Source Type: research

Identification of C-terminal Hsp70-interacting protein as a mediator of tumour necrosis factor action in osteoblast differentiation by targeting osterix for degradation.
Abstract In patients with inflammatory arthritis, tumour necrosis factor (TNF)-α are overproduced in inflamed joints. This leads to local erosion of cartilage and bone, periarticular osteopenia, as well as osteoporosis. But less is known regarding the molecular mechanisms that mediate the effect of TNF-α on osteoblast function. The purpose of this study was to test that C terminus of Hsc70-interacting protein (CHIP) has a specific role in suppressing the osteogenic activity of osteoblasts under inflammatory conditions. C2C12, MC3T3-E1 and HEK293T cell lines were cultured and cotransfected with related plasmids. ...
Source: J Cell Mol Med - March 26, 2015 Category: Molecular Biology Authors: Xie J, Gu J Tags: J Cell Mol Med Source Type: research