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Epigenetic suppression of potassium ‐chloride co‐transporter 2 expression in inflammatory pain induced by complete Freund's adjuvant (CFA)
ConclusionThese findings suggest that the transcription of spinal KCC2 is regulated by histone acetylation epigenetically following CFA. SignificancePersistent pain suppresses KCC2 expression through HDAC‐mediated histone hypoacetylation and consequently impairs the inhibitory function of inhibitory interneurons. Drugs such as HDAC inhibitors that suppress the influences of persistent pain on the expression of KCC2 may serve as a novel analgesic.
Source: European Journal of Pain - August 10, 2016 Category: Anesthesiology Authors: C. ‐R. Lin, J.‐K. Cheng, C.‐H. Wu, K.‐H. Chen, C.‐K. Liu Tags: Original Article Source Type: research

Positive feedback regulation between microRNA‐132 and CREB in spinal cord contributes to bone cancer pain in mice
ConclusionsThese findings suggest that activation of spinal CREB/CRTC1 signalling may play an important role in bone cancer pain. Interruption to the positive feedback regulation between CREB/CRTC1 and its target gene miR‐132 can effectively relieved the bone cancer‐induced mechanical allodynia and spontaneous pain. What does this study add?The positive feedback regulation between CREB/CRTC1 and its target gene miR‐132 in spinal cord plays an important role in bone cancer pain.
Source: European Journal of Pain - February 26, 2016 Category: Anesthesiology Authors: B. Hou, X. Cui, Y. Liu, W. Zhang, M. Liu, Y.E. Sun, Z. Ma, X. Gu Tags: Original Article Source Type: research

Positive feedback regulation between microRNA ‐132 and CREB in spinal cord contributes to bone cancer pain in mice
ConclusionsThese findings suggest that activation of spinal CREB/CRTC1 signalling may play an important role in bone cancer pain. Interruption to the positive feedback regulation between CREB/CRTC1 and its target gene miR‐132 can effectively relieved the bone cancer‐induced mechanical allodynia and spontaneous pain. What does this study add?The positive feedback regulation between CREB/CRTC1 and its target gene miR‐132 in spinal cord plays an important role in bone cancer pain.
Source: European Journal of Pain - February 25, 2016 Category: Anesthesiology Authors: B. Hou, X. Cui, Y. Liu, W. Zhang, M. Liu, Y.E. Sun, Z. Ma, X. Gu Tags: Original Article Source Type: research

NRG1‐ErbB signalling promotes microglia activation contributing to incision‐induced mechanical allodynia
ConclusionIncision‐induced NRG1 expression mediated activation of dorsal horn microglia and contributed to the development of mechanical allodynia. Specifically targeting NRG1‐ErbB signalling may therefore provide a new therapeutic intervention for relieving incision‐induced mechanical allodynia.
Source: European Journal of Pain - August 27, 2014 Category: Anesthesiology Authors: Y. Xiang, T. Liu, H. Yang, F. Gao, H. Xiang, A. Manyande, Y. Tian, X. Tian Tags: Original Article Source Type: research