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ASIC1a-CMPK2-mediated M1 macrophage polarization exacerbates chondrocyte senescence in osteoarthritis through IL-18
CONCLUSION: These results demonstrate a novel pathogenic process that results in OA cartilage damage, in which M1 macrophage derived IL-18 induces articular chondrocytes senescence. Further, the ASIC1a-CMPK2 axis was shown to positively regulate M1 macrophage polarization. Hence, ASIC1a is a promising treatment target for M1 macrophage-mediated diseases, such as OA.PMID:37660594 | DOI:10.1016/j.intimp.2023.110878
Source: International Immunopharmacology - September 3, 2023 Category: Allergy & Immunology Authors: Lei Dong Yingjie Zhao Cheng Sun Ziwei Ou Yang Fan Chen Weirong Hu Hailin Zhang Yan Wang Rendi Zhu Yuanzhi Cheng Yong Chen Shufang Li Ke Wang Changhai Ding Renpeng Zhou Wei Hu Source Type: research

Stevioside protects primary articular chondrocytes against IL-1 β-induced inflammation and catabolism by targeting integrin
Int Immunopharmacol. 2023 May 9;119:110261. doi: 10.1016/j.intimp.2023.110261. Online ahead of print.ABSTRACTOsteoarthritis (OA) is a common, progressive, and chronic disorder of the joints that is characterized by the inflammation and degradation of articular cartilage and is known to significantly impair quality of daily life. Stevioside (SVS) is a natural diterpenoid glycoside that has anti-inflammatory benefits. Hence, in the current research, it was hypothesized that SVS might exert anti-inflammatory effects on articular chondrocytes and alleviate cartilage degradation in mice with OA. The expression of inflammatory c...
Source: International Immunopharmacology - May 11, 2023 Category: Allergy & Immunology Authors: Junlai Wan Ziqing Zhu Zhiyi He Hua Wu Anmin Chen Wentao Zhu Peng Cheng Source Type: research

CX-4945 inhibits fibroblast-like synoviocytes functions through the CK2-p53 axis to reduce rheumatoid arthritis disease severity
Int Immunopharmacol. 2023 Apr 13;119:110163. doi: 10.1016/j.intimp.2023.110163. Online ahead of print.ABSTRACTFibroblast-like synoviocytes (FLS) mediate many pathological processes in rheumatoid arthritis (RA), including pannus formation, bone erosion, and inflammation. RA FLS have unique aggressive phenotypes and exhibit several tumor cell-like characteristics, including hyperproliferation, excessive migration and invasion. Casein kinase 2 (CK2) is reportedly overexpressed in numerous tumor types, and targeted inhibition of CK2 has therapeutic benefits for tumors. However, the expression level of CK2 and its functions in ...
Source: International Immunopharmacology - April 15, 2023 Category: Allergy & Immunology Authors: Yanping Luo Yunxuan Lei Xin Guo Dehao Zhu Haiyang Zhang Zizhen Guo Zichong Xu Hanqing Zhao Yebin Xi Xiaochun Peng Lianbo Xiao Zhaojun Wang Xiaoyin Niu Guangjie Chen Source Type: research

Indole-3-aldehyde alleviates chondrocytes inflammation through the AhR-NF- κB signalling pathway
CONCLUSIONS: 3-IAld reduced inflammation through the AhR-NF-κB signalling pathway in IL-1β-induced chondrocytes, which is expected to provide a new therapeutic strategy for OA.PMID:36252481 | DOI:10.1016/j.intimp.2022.109314
Source: International Immunopharmacology - October 17, 2022 Category: Allergy & Immunology Authors: Huangming Zhuang Bin Li Ting Xie Changgeng Xu Xunshan Ren Fuze Jiang Tianrun Lei Panghu Zhou Source Type: research

Inhibition of GPR17 with pranlukast protects against TNF- α-induced loss of type II collagen in ATDC5 cells.
In this study, we demonstrate that GPR17 is expressed in ATDC5 cells and is increased in response to TNF-α exposure. We also found that antagonism of GPR17 with pranlukast significantly inhibited oxidative stress by downregulating the intracellular level of reactive oxygen species (ROS) and increasing the activity of super oxide dismutase (SOD) against TNF-α. Interestingly, treatment with pranlukast prevented TNF-α-induced reduction of type II collagen. Additionally, knockdown of GPR17 with siRNA ameliorated TNF-α-induced loss of type II collagen, suggesting the importance of the role of GPR17 in mediating the impairme...
Source: International Immunopharmacology - August 13, 2020 Category: Allergy & Immunology Authors: Wang Z, Zhou W, Zheng G, Yang G Tags: Int Immunopharmacol Source Type: research

Eupatilin protects chondrocytes from apoptosis via activating sestrin2-dependent autophagy.
Abstract Cartilage degradation is the main characterization of osteoarthritis (OA). Accumulating evidence suggests that chondrocyte apoptosis and autophagy are associated with cartilage degradation. Thus, we investigated the protective effect and underlying mechanism of eupatilin for treating OA. IL-1β was used to simulate OA in vitro. Data show that eupatilin treatment attenuated IL-1β-induced apoptosis of chondrocytes. Autophagy was also activated by eupatilin in a dose-dependent manner. Then, pretreatment with chloroquine (CQ), an autophagic inhibitor, decreased eupatilin-induced autophagy and increased apopt...
Source: International Immunopharmacology - July 11, 2019 Category: Allergy & Immunology Authors: Lou Y, Wu J, Liang J, Yang C, Wang K, Wang J, Guo X Tags: Int Immunopharmacol Source Type: research

Dihydroartemisinin derivative DC32 inhibits inflammatory response in osteoarthritic synovium through regulating Nrf2/NF- κB pathway.
In conclusion, DC32 inhibited the inflammatory response in osteoarthritic synovium through regulating Nrf2/NF-κB pathway and attenuated OA. In this way, DC32 may be a potential agent in the treatment of OA. PMID: 31228817 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - June 18, 2019 Category: Allergy & Immunology Authors: Li YN, Fan ML, Liu HQ, Ma B, Dai WL, Yu BY, Liu JH Tags: Int Immunopharmacol Source Type: research

Role of the ciRS-7/miR-7 axis in the regulation of proliferation, apoptosis and inflammation of chondrocytes induced by IL-1 β.
In this study, quantitative reverse-transcription PCR (qRT-PCR) was utilized to determine the relative expression of ciRS-7 and miR-7 in blood samples from OA patients compared with those from healthy individuals. Human OA chondrocytes (C28/12 cell line) were transfected with ciRS-7-siRNA, ciRS-7-cDNA, inhibitor or miR-7 mimic to investigate the influence of ciRS-7/miR-7 expression on chondrocyte apoptosis, inflammation and related signaling pathways. Decreased ciRS-7 expression and increased miR-7 expression were observed in OA blood samples. IL-1β exposure of chondrocytes significantly inhibited proliferation and promot...
Source: International Immunopharmacology - March 25, 2019 Category: Allergy & Immunology Authors: Zhou X, Jiang L, Fan G, Yang H, Wu L, Huang Y, Xu N, Li J Tags: Int Immunopharmacol Source Type: research