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Targeted inhibition of TXNRD1 prevents cartilage extracellular matrix degeneration by activating Nrf2 pathway in osteoarthritis
Biochem Biophys Res Commun. 2022 Oct 19;635:267-276. doi: 10.1016/j.bbrc.2022.10.059. Online ahead of print.ABSTRACTOsteoarthritis, a prevalent orthopedic disease, can affect the elderly and causes impairment. The degradation and aberrant homeostasis of cartilage extracellular matrix figure pivotally in the progression of osteoarthritis. Thioredoxin systems plays a role in a wide range of biological processes, including cell proliferation, apoptosis, and oxidative stress. The present study aimed to investigate the unique function and underlying pathophysiological mechanism of TXNRD1 in chondrocytes. An upregulated expressi...
Source: Biochemical and Biophysical Research communications - October 29, 2022 Category: Biochemistry Authors: Jianhui Liang Song Wang Jiawei Hu Xin Hong Meisong Zhu Xuqiang Liu Momen Alswadeh Fengbo Mo Min Dai Source Type: research

Inhibition of GAB2 expression has a protective effect on osteoarthritis:An in  vitro and in vivo study
In conclusion, our study demonstrates that GAB2 is a potential therapeutic target for OA.PMID:36007472 | DOI:10.1016/j.bbrc.2022.08.006
Source: Biochemical and Biophysical Research communications - August 25, 2022 Category: Biochemistry Authors: Haokun Mo Siying Yang An-Min Chen Source Type: research

Swelling-activated ClC-3 activity regulates prostaglandin E2 release in human OUMS-27 chondrocytes.
In this study, we reveal that in human OUMS-27 chondrocytes, ICl,swell can be elicited by hypoosmotic stimulation (180 mOsm) and be inhibited by classical Cl- channel blockers, 4,4'-diisothiocyano-2,2'-stilbenedisulfonic acid (DIDS) and niflumic acid, and be attenuated by siRNA knockdown of ClC-3. Our molecular analyses revealed that ClC-3A is expressed as a major splice variant in both human articular chondrocytes and OUMS-27 cells. The onset and early phase of RVD following hypoosmotic stress in OUMS-27 cells were affected by DIDS and ClC-3 knockdown. Hypoosmotic stimulation caused Ca2+ influx and subsequent release of...
Source: Biochemical and Biophysical Research communications - December 28, 2020 Category: Biochemistry Authors: Yamada S, Suzuki Y, Bernotiene E, Giles WR, Imaizumi Y, Yamamura H Tags: Biochem Biophys Res Commun Source Type: research

Up-regulation of TRAF2 inhibits chondrocytes apoptosis in lumbar facet joint osteoarthritis.
In conclusion, our results show that the up-regulation of TRAF2 may play an important role in the inhibition of chondrocyte apoptosis of FJOA. PMID: 30054040 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - July 24, 2018 Category: Biochemistry Authors: Jiang J, Zhang J, Wu C, Guo X, Chen C, Bao G, Sun Y, Chen J, Xue P, Xu G, Cui Z Tags: Biochem Biophys Res Commun Source Type: research