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Ulcerative Colitis-Associated Long Noncoding RNA, BC012900, Regulates Intestinal Epithelial Cell Apoptosis
Conclusions: Multiple lncRNAs are differentially expressed in IBD and play a role in regulating cellular physiology. Our results indicate that lncRNAs may be integral modulators of intestinal inflammation associated with IBD and represent novel targets for future therapeutics and diagnostic marker development.
Source: Inflammatory Bowel Diseases - March 15, 2016 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research

Increased Expression of Interleukin-36, a Member of the Interleukin-1 Cytokine Family, in Inflammatory Bowel Disease
Conclusions: IL-36α and IL-36γ may play a proinflammatory role in the pathophysiology of inflammatory bowel disease through induction of CXC chemokines and acute phase proteins.
Source: Inflammatory Bowel Diseases - January 24, 2016 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research

Heterogeneous Nuclear Ribonucleoprotein A1 Improves the Intestinal Injury by Regulating Apoptosis Through Trefoil Factor 2 in Mice with Anti-CD3–induced Enteritis
Conclusions: hnRNP A1 improves intestinal injury in anti-CD3 antibody–induced enteritis mice through the upregulation of TFF2, which regulates apoptosis and enhances epithelial restoration, whereas this molecule ameliorates DSS-induced colitis through a different pathway.
Source: Inflammatory Bowel Diseases - June 16, 2015 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research