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Intracameral Delivery of Layer ‐by‐Layer Coated siRNA Nanoparticles for Glaucoma Therapy
Nanoparticles loaded with siRNA against connective tissue growth factor (CTGF) and coated with a final layer of hyaluronan (HA) are proposed as a novel and causative approach for glaucoma treatment. HA ‐coated nanoparticles deeply penetrate into the outflow region of porcine, murine, and human eyes ex vivo and have the capability of silencing CTGF in cultures of human trabecular meshwork cells. AbstractGlaucoma is the second leading cause of blindness worldwide, often associated with elevated intraocular pressure. Connective tissue growth factor (CTGF) is a mediator of pathological effects in the trabecular meshwork (TM)...
Source: Small - December 13, 2018 Category: Nanotechnology Authors: Andrea E. Dillinger, Michaela Guter, Franziska Froemel, Gregor R. Weber, Kristin Perkumas, W. Daniel Stamer, Andreas Ohlmann, Rudolf Fuchshofer, Miriam Breunig Tags: Full Paper Source Type: research