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Condition: Diabetes
Infectious Disease: Dengue Fever
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Total 2 results found since Jan 2013.
Dengue virus is involved in insulin resistance via the downregulation of IRS-1 by inducing TNF- α secretion
Biochim Biophys Acta Mol Basis Dis. 2022 Jun 22:166472. doi: 10.1016/j.bbadis.2022.166472. Online ahead of print.ABSTRACTDuring the epidemic, the individuals with underlying diseases usually have a higher rate of mortality. Diabetes is highly prevalent worldwide, making it a frequent comorbidity in dengue fever patients. Therefore, understanding the relationship between dengue virus (DENV) infection and diabetes is important. We first demonstrated that DENV-3 infection down-regulated the expression of IRS-1. In vitro, treatment of HepG2 cells with TNF-α inhibitors and siRNA proved that after DENV-3 infection in HepG2 cell...
Source: Biochimica et Biophysica Acta - June 25, 2022 Category: Biochemistry Authors: Xuling Liu Zuxin Liang Hongwei Duan Jianhai Yu Zhiran Qin Jingshu Li Li Zhu Qinghua Wu Weiwei Xiao Chenguang Shen Chengsong Wan Kefeng Wu Hua Ye Bao Zhang Wei Zhao Source Type: research
