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Equol is neuroprotective during focal cerebral ischemia and reperfusion that involves p-Src and gp91phox.
Abstract Both of gp91(phox) (an isoform of nicotinamide adenine dinucleotide phosphate reduced oxidases) and Src (a non-receptor protein tyrosine kinase) are abundantly expressed in the brain and play a prominent role in mediating ischemic alteration in neurons. The inhibitory strategy of them is believed to be the promising treatment of stroke. The present study was designed to investigate the effect of equol (0.625-2.5 mg•kg(-1), i.g. for 3 days), a predominant active metabolite of daidzein, on neuroprotection against cerebral ischemia/reperfusion injury in rats and the underlying mechanisms. We found that equ...
Source: Current Neurovascular Research - September 7, 2014 Category: Neurology Authors: Wei YU, Wang Y, Zhou DX, Zhao LM, Li GR, Deng XL Tags: Curr Neurovasc Res Source Type: research