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Silencing of GPR82 with Interference RNA Improved Metabolic Profiles in Rats with High Fructose Intake
Metabolic syndrome (MS) is a clinical condition, constituted by alterations that lead to the onset of type II diabetes and cardiovascular disease. It has been reported that orphan G-protein-coupled receptor 82 (GPR82) participates in metabolic processes. The aim of this study was to evaluate the  function of GPR82 in MS using a small interfering RNA (siRNA) against this receptor. We used Wistar rats of 10–12 weeks of age fed with a high-fructose solution (70%) for 9 weeks to induce MS. Subsequently, the rats were treated with an intrajugular dose of an siRNA against GPR82 and the effects were evaluated on day 3 and 7 af...
Source: Journal of Vascular Research - July 2, 2019 Category: Research Source Type: research

Repin1 deficiency in liver tissue alleviates NAFLD progression in mice
This study provides evidence that loss of Repin1 in the liver attenuates NAFLD progression, most likely by reducing fat accumulation and alleviating chronic tissue inflammation. Thus, modulating Repin1 expression may become a novel strategy and potential tool to inhibit NAFLD progression.Graphical abstract
Source: Journal of Advanced Research - November 23, 2018 Category: Research Source Type: research

Resistin affects lipid metabolism during adipocyte maturation of 3T3‐L1 cells
This article is protected by copyright. All rights reserved.
Source: FEBS Journal - September 5, 2013 Category: Research Authors: Yoshito Ikeda, Hiroyuki Tsuchiya, Susumu Hama, Kazuaki Kajimoto, Kentaro Kogure Tags: Original Article Source Type: research