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A ‘synthetic-sickness’ screen for senescence re-engagement targets in mutant cancer backgrounds
by Claire J. Cairney, Lauren S. Godwin, Alan E. Bilsland, Sharon Burns, Katrina H. Stevenson, Lynn McGarry, John Revie, Jon D. Moore, Ceri M. Wiggins, Rebecca S. Collinson, Clare Mudd, Elpida Tsonou, Mahito Sadaie, Dorothy C. Bennett, Masashi Narita, Christopher J. Torrance, W. Nicol Keith Senescence is a universal barrier to immortalisation and tumorigenesis. As such, interest in the use of senescence-induction in a therapeutic context has been gaining momentum in the past few years; however, senescence and immortalisation remain underserved areas for drug discovery owing to a lack of robust senescence inducing agents an...
Source: PLoS Genetics - August 14, 2017 Category: Genetics & Stem Cells Authors: Claire J. Cairney Source Type: research

GSE72055 Human telomerase RNA processing and quality control
Contributors : Chi K Tang ; Hui F Wang ; Allison M Burns ; Morgan R Schroeder ; Martina Gaspari ; Peter BaumannSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA sequencing of HeLa cells treated with siRNA against the RNA exosome components hRRP40, hRRP6, hDIS3, and hRRP6/hDIS3 or the splicing inhibitors Isoginkgetin and spliceostatin A, respectively.
Source: GEO: Gene Expression Omnibus - November 25, 2015 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research