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SIRT2 regulates insulin sensitivity in insulin-resistant neuronal cells.
In this study, we report the role of SIRT2 in regulating insulin-sensitivity in neuronal cells in vitro. Using approaches like pharmacological inhibition of SIRT2, siRNA mediated SIRT2 knockdown and over-expression of wild-type and catalytically-mutated SIRT2, we observed that downregulation of SIRT2 ameliorated the reduced activity of AKT and increased insulin-stimulated glucose uptake in insulin resistant neuro-2a cells. The data was supported by over expression of catalytically-inactive SIRT2 in insulin-resistant human SH-SY5Y neuronal cells. Data highlights a crucial role of SIRT2 in regulation of neuronal insulin sens...
Source: Biochemical and Biophysical Research communications - May 5, 2016 Category: Biochemistry Authors: Arora A, Dey CS Tags: Biochem Biophys Res Commun Source Type: research