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Specialty: Cytology
Condition: Huntington's Disease
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Total 1 results found since Jan 2013.
Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels
Autophagy. 2021 May 24:1-22. doi: 10.1080/15548627.2021.1904489. Online ahead of print.ABSTRACTCurrent disease-modifying therapies for Huntington disease (HD) focus on lowering mutant HTT (huntingtin; mHTT) levels, and the immunosuppressant drug rapamycin is an intriguing therapeutic for aging and neurological disorders. Rapamycin interacts with FKBP1A/FKBP12 and FKBP5/FKBP51, inhibiting the MTORC1 complex and increasing cellular clearance mechanisms. Whether the levels of FKBP (FK506 binding protein) family members are altered in HD models and if these proteins are potential therapeutic targets for HD have not been invest...
Source: Autophagy - May 24, 2021 Category: Cytology Authors: Barbara J Bailus Stephen M Scheeler Jesse Simons Maria A Sanchez Kizito-Tshitoko Tshilenge Jordi Creus-Muncunill Swati Naphade Alejandro Lopez-Ramirez Ningzhe Zhang Kuruwitage Lakshika Madushani Stanislav Moroz Ashley Loureiro Katherine H Schreiber Felix Source Type: research
