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Current Therapeutic Advances in Patients and Experimental Models of Huntington's Disease.
Abstract Huntington's disease (HD) clinical manifestations begin insidiously and are progressively incapacitating. Symptomatic therapies, in particular dopamine blockers and neuroleptics, are presently the only treatment for HD. Identification of neuropathological mechanisms that underlie the selective striatal and cortical neurodegeneration has allowed for the development of novel neuroprotective therapies that may improve HD patients' quality of life and enhance their survival. In this review we describe the symptomatic and neuroprotective therapies in HD that are currently in a pre-clinical or clinical stage. N...
Source: Current Drug Targets - November 24, 2013 Category: Drugs & Pharmacology Authors: Brett AC, Rosenstock TR, Rego AC Tags: Curr Drug Targets Source Type: research