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Interference with the expression of S1PR1 or STAT3 attenuates valvular damage due to rheumatic heart disease
Int J Mol Med. 2021 Sep;48(3):179. doi: 10.3892/ijmm.2021.5012. Epub 2021 Jul 23.ABSTRACTRheumatic heart disease (RHD) affects numerous individuals annually; however, its pathogenesis remains unclear. The sphingosine 1‑phosphate receptor 1 (S1PR1) and signal transducer and activator of transcription 3 (STAT3) have recently been shown to be involved in valvular damage via the promotion of the differentiation of T helper 17 (Th17) cells during the development of RHD‑induced valvular damage. The present study investigated whether altering the expression of S1PR1 or STAT3 attenuates valvular damage due to RHD. Inactivated ...
Source: International Journal of Molecular Medicine - July 23, 2021 Category: Molecular Biology Authors: Shenglin Xian Ang Chen Yunjiao Wu Hong Wen Chuanghong Lu Feng Huang Zhiyu Zeng Source Type: research

PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF ‑R.
PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF‑R. Int J Mol Med. 2018 Mar 09;: Authors: Zhao Q, Liu Z, Huang B, Yuan Y, Liu X, Zhang H, Qiu F, Zhang Y, Li Y, Miao H, Dong H, Zhang Z Abstract The prevention and management of myocardial ischemia/reperfusion (MI/R) injury is an essential part of coronary heart disease surgery and is becoming a major clinical problem in the treatment of ischemic heart disease. Previous studies by our group have demonstrated that pigment epithelium‑derived factor (PEDF) improves cardiac f...
Source: International Journal of Molecular Medicine - March 9, 2018 Category: Molecular Biology Authors: Zhao Q, Liu Z, Huang B, Yuan Y, Liu X, Zhang H, Qiu F, Zhang Y, Li Y, Miao H, Dong H, Zhang Z Tags: Int J Mol Med Source Type: research